Application of SF3B as target in preparation of drugs for preventing or treating breast cancer
A technology of SF3B1 and breast cancer, applied in the field of biomedicine, can solve problems such as unclear SF3B1 breast cancer
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[0025] According to the guidelines of the local ethics committee, cancer tissue samples from 110 patients diagnosed with breast cancer were obtained from the First Affiliated Hospital of Shanxi Medical University, 40 of which had matching non-tumor control tissues. Molecular subtypes include Luminal A (38), Luminal B (38), HER2-enriched (14) and triple-negative / basal-like breast cancer (20). None of the patients received radiation or chemotherapy before surgery.
[0026] Immunohistochemistry: Paraffin-embedded formalin-fixed tissue samples were used for immunohistochemistry. Cut the specimen into 4 μm thick slices. Sections were deparaffinized and rehydrated using graded xylene and ethanol. Then the sample was washed with 3% H 2 o 2 Incubate for 10-15 min and rinse three times with distilled water. After antigen extraction in sodium citrate buffer (pH 6.0) for 2 min and blocking in goat serum, sections were incubated with specific anti-SF3B1 antibody (Abcam) diluted 1:200...
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