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Application of Shuangjiang Weitong Recipe in the preparation of medicaments for the treatment of inflammatory bowel disease

A kind of pain recipe and medicine technology, applied in the application field of Shuangjiang Weitong recipe in the preparation of medicines for treating inflammatory bowel disease, can solve the problems such as insufficient exploration and utilization of medicinal uses, achieve good application prospects, reduce vitality, The effect of lowering the activity index

Active Publication Date: 2021-11-23
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Shuang Jiang Wei Tong Fang is used for patients with the above symptoms of chronic superficial gastritis caused by epigastric fullness and pain, belching and acid regurgitation caused by qi stagnation in the middle energizer, but its medical use has not been fully explored and utilized.

Method used

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  • Application of Shuangjiang Weitong Recipe in the preparation of medicaments for the treatment of inflammatory bowel disease
  • Application of Shuangjiang Weitong Recipe in the preparation of medicaments for the treatment of inflammatory bowel disease
  • Application of Shuangjiang Weitong Recipe in the preparation of medicaments for the treatment of inflammatory bowel disease

Examples

Experimental program
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preparation example Construction

[0020] The preparation method of Shuangjiang Weitong prescription is as follows: according to the weight ratio of 1:1:1:1:1, take turmeric, purple ginger, dirong, Shichangpu, and bitter rapeseed, and add 4-5 L per 500g of the total weight of medicinal materials. After soaking in ethanol, heat to reflux, filter, and extract the filter residue with ethanol reflux for 2-3 times, combine the filtrate, concentrate under reduced pressure, dry, and grind finely to obtain Shuangjiang Weitong Formula.

[0021] The concentration of ethanol is 75%.

[0022] The drying method is vacuum drying under reduced pressure.

[0023] Application of Shuangjiang Weitong Prescription in the preparation of medicine for treating ulcerative colitis.

[0024] Application of Shuangjiang Weitong Prescription in preparation of medicament for treating colonic inflammation induced by dextran sodium sulfate in mice.

[0025] The Shuangjiang Weitong prescription comprises a therapeutically effective dose of S...

Embodiment 1

[0029] Example 1 Preparation of Shuangjiang Weitong Prescription

[0030] Weigh 100 g each of turmeric, purple ginger, dirong, calamus, and bitter cabbage (500 g in total), put them in a 5 L round bottom flask, add 5 L of 75% ethanol, soak for 1 h, add 5 L, 4 L, 4L of 75% ethanol was extracted once by reflux in each water bath, and the extraction time was 1.5 h, 1 h, and 0.5 h respectively. The filtrates were combined three times, and the ethanol was recovered under reduced pressure until there was no alcohol smell, and then placed in a vacuum decompression drying oven, dried, and ground to obtain Extract, the extraction rate is 43%, for subsequent use.

Embodiment 2

[0032] The extract obtained in Example 1 was taken, concentrated, evaporated to dryness under reduced pressure, pulverized and sieved to obtain dry cream powder, which was packed into capsules to obtain capsules.

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Abstract

The invention discloses the application of a Shuangjiang Weitong prescription in the preparation of medicaments for treating inflammatory bowel disease. The Shuangjiang Weitong prescription comprises turmeric, purple ginger, dirong, Shichangpu and bitter colza according to the ratio of 1:1:1: The extracts are mixed in a 1:1 ratio by weight. Tests have shown that Shuangjiang Weitong Prescription can significantly improve the colonic inflammation induced by dextran sodium sulfate in mice, manifested as significantly reducing the disease activity index in mice, significantly improving the shortening of mouse colon length caused by modeling; significantly reducing the level of MPO in serum Vitality; significantly reduce the content of pro-inflammatory cytokines IL-1β, IL-6 and IL-1β in colon tissue, have significant anti-ulcerative colitis activity, and have good application prospects in the preparation of drugs for the treatment of inflammatory bowel disease .

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the application of Shuangjiang Weitong Prescription in the preparation of medicines for treating inflammatory bowel disease. Background technique [0002] The standard number of Shuangjiang Weitong Prescription is WS-11105 (ZD-1105) -2002, which is recorded in the Spleen and Stomach Subvolume of the National Compilation of Chinese Patent Medicine Standards. It is made of 200g of turmeric, 200g of purple ginger, 200g of dirong, 200g of Shichangpu, and 200g of bitter rapeseed as raw materials. It has the effects of regulating qi and relieving pain, and regulating the stomach. [0003] Shuangjiang Weitong prescription is used for patients with epigastric fullness, fullness, pain, belching and acid regurgitation, and chronic superficial gastritis caused by qi stagnation in the middle energizer. However, its medical use has not been fully explored and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P29/00A61P1/00
CPCA61K36/28A61K36/59A61K36/888A61K36/9066A61K36/9068A61K2236/333A61K2236/39A61P1/00A61P29/00A61K2300/00
Inventor 王亭郭雪艳毛晓健李宝晶
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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