Preparation method of silymarin skin care product

A technology of silymarin and skin care products, which is applied in the field of preparation of silymarin skin care products, can solve the problems of silymarin uneven distribution, instability, and easy clogging of skin pores, and achieve the effects of avoiding clogging of skin pores, easy absorption, and avoiding damage

Active Publication Date: 2020-02-11
ZHONGXING PHARM CO LTD JIANGSU
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Research data show that silymarin has anti-aging and anti-radiation effects in clinical practice. According to the above-mentioned efficacy characteristics of silymarin, many research institutes at home and abroad have actively carried out research on the use of silymarin in cosmetic and skin care products. Currently, through the water-oil wrapping technology of cosmetics Although it solves the technical requirement of non-layering of cosmetics in the container, due to the special nature of silymarin as a fat-soluble substance, the method of water and oil wrapping can only solve the separation of silymarin macromolecules, and cannot fundamentally change the fact that silymarin is not conducive to skin absorption. Features, the current silymarin skin care products have the following problems: (1) the distribution of silymarin in the cosmetic matrix is ​​uneven and unstable; (2) it is difficult to be absorbed by the skin, and it is easy to block the pores of the skin after long-term use

Method used

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  • Preparation method of silymarin skin care product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A preparation method of a silymarin skin care product, the dosage formula of each substance is as follows:

[0029] Silymarin: 100g

[0030] Meglumine: 20g

[0031] Anhydrous ethanol: 300g

[0032] Deionized water: 600g

[0033] Gelatin: 240g

[0034] Glycerin: 600g

[0035] Sodium benzoate: 1.2g;

[0036] The preparation method is as follows:

[0037] (1) Weighing 100g of silymarin and 20g of meglumine were dissolved in 300g of absolute ethanol, and slightly boiled for 40min;

[0038] (2) reclaim the absolute ethanol in the silymarin meglumine absolute ethanol solution:

[0039] A) Add the silymarin meglumine solution into a rotary water-bath thin-film evaporator, and rotate while heating at 70°C at a speed of 60r / min. After the solution starts to reflux, turn on the vacuum, and the vacuum degree is -0.06MPa for recovery. Ethanol, heating and selection are performed simultaneously;

[0040] B) heating at 100°C, and keeping the rotation speed until the silymari...

Embodiment 2

[0046] A preparation method of a silymarin skin care product, the dosage formula of each substance is as follows:

[0047] Silymarin: 100g

[0048] Meglumine: 30g

[0049] Absolute ethanol: 520g

[0050] Deionized water: 1250g

[0051] Gelatin: 400g

[0052] Glycerin: 1000g

[0053] Sodium benzoate: 1g;

[0054] The preparation process steps are as follows:

[0055] (1) Weighing 100g of silymarin and 30g of meglumine were dissolved in 520g of absolute ethanol, and slightly boiled for 45min;

[0056] (2) reclaim the absolute ethanol in the silymarin meglumine absolute ethanol solution:

[0057] A) Add the silymarin meglumine solution into a rotary water-bath thin-film evaporator, and rotate while heating at 80°C at a speed of 70r / min. After the solution starts to reflux, turn on the vacuum, and the vacuum degree is -0.07MPa for recovery. Ethanol, heating and selection are performed simultaneously;

[0058] B) heating at 100°C, and keeping the rotation speed until the s...

Embodiment 3

[0064] A preparation method of a silymarin skin care product, the dosage formula of each substance is as follows:

[0065] Silymarin: 100g

[0066] Meglumine: 50g

[0067] Absolute ethanol: 750g

[0068] Deionized water: 1800g

[0069] Gelatin: 450g

[0070] Glycerin: 1050g

[0071] Sodium benzoate: 0.45g;

[0072] Process steps:

[0073] (1) Weighing 100g of silymarin and 50g of meglumine were dissolved in 750g of absolute ethanol, and slightly boiled for 50min;

[0074] (2) reclaim the absolute ethanol in the silymarin meglumine absolute ethanol solution:

[0075] A) Add the silymarin meglumine solution into a rotary water-bath thin-film evaporator, and rotate while heating at 100°C at a speed of 100r / min. After the solution starts to reflux, turn on the vacuum, and the vacuum degree is -0.08MPa for recovery Ethanol, heating and selection are performed simultaneously;

[0076] B) heating at 100°C, and keeping the rotation speed until the silymarin meglumine solution b...

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Abstract

The invention discloses a preparation method of a silymarin skin care product. The preparation method comprises the following steps: dissolving the silymarin and meglumine in absolute ethyl alcohol, heating the mixture and then recovering the absolute ethyl alcohol, thereby obtaining a silymarin-meglumine raw material; and evenly mixing the silymarin-meglumine raw material with deionized water, placing the mixture in a stirrer, stirring the mixture, adding gelatin and glycerol, further stirring the mixture, adding sodium benzoate and carrying out an ultrasonic processing, thereby obtaining thedesired silymarin skin care product. The invention solves the defects that the traditional preparation method directly adopts the silymarin to prepare related skin care products, resulting in excessive facial skin grease and pore blockage after long-term use; and the silymarin-meglumine and the sodium benzoate are uniformly distributed in other matrixes by ultrasonic even-mixing technology, and the silymarin-meglumine can not be decomposed or damaged.

Description

technical field [0001] The invention relates to the field of preparation methods of skin care products, in particular to a preparation method of silymarin skin care products. Background technique [0002] Research data show that silymarin has anti-aging and anti-radiation effects in clinical practice. According to the above-mentioned efficacy characteristics of silymarin, many research institutes at home and abroad have actively carried out research on the use of silymarin in cosmetic and skin care products. Currently, through the water-oil wrapping technology of cosmetics Although it solves the technical requirement of non-layering of cosmetics in the container, due to the special nature of silymarin as a fat-soluble substance, the method of water and oil wrapping can only solve the separation of silymarin macromolecules, and cannot fundamentally change the fact that silymarin is not conducive to skin absorption. Features, the current silymarin skin care products have the f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/65A61K8/34A61K8/41A61K8/49A61Q17/04A61Q19/08
CPCA61K8/498A61K8/41A61K8/65A61K8/345A61Q19/08A61Q17/04A61K2800/82
Inventor 武俊明
Owner ZHONGXING PHARM CO LTD JIANGSU
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