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A fusion protein targeting antigen-specific T cells to induce their differentiation into memory stem cells

A fusion protein and cell technology, applied in the field of fusion proteins, can solve problems such as inflammation and insignificant anti-tumor effect.

Active Publication Date: 2022-01-18
乘典(苏州)生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since IL-21 can also act on a variety of other immune cells and tissue cells, the anti-tumor effect of systemic application in clinical trials is not obvious, and long-term application will cause side effects such as inflammation

Method used

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  • A fusion protein targeting antigen-specific T cells to induce their differentiation into memory stem cells
  • A fusion protein targeting antigen-specific T cells to induce their differentiation into memory stem cells
  • A fusion protein targeting antigen-specific T cells to induce their differentiation into memory stem cells

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Embodiment Construction

[0014] Unless otherwise specified or defined, all terms used have meanings commonly used in the art, which are clear to a skilled person. For example, reference is made to standard handbooks such as Sambrook et al., "Molecular Cloning: A Laboratory Manual" (2nd Edition), Vols. 1-3, Green Publishing and Wiley Interscience, New York (1987); Lewin, "Genes II", John Wiley & Sons, New York, N.Y., (1985); Old et al., "Principles of Gene Manipulation: An Introduction to Genetic Engineering", 2nd ed., University of California Press, Berkeley, CA (1981); Roitt et al., "Immunology" (6th ed.), Mosby / Elsevier, Edinburgh (2001); Roitt et al., Roitt's Essential Immunology (Roitt's Basic Immunology), 10th Edition. Blackwell Publishing, UK (2001); and Janeway et al., "Immunobiology (Immunology)" (6th Edition), Garland Science Publishing / Churchill Livingstone, New York (2005), and the known background technologies cited therein;

[0015] The terms "amino-terminal" and "carboxy-terminal" as u...

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Abstract

The present invention relates to an anti-PD-1 antibody and IL-21 fusion protein, the fusion protein can not only block the combination of PD-L1 and PD-1 on the surface of T cells, exert the tumor treatment effect of anti-PD-1 antibody, but also It can target IL-21 to tumor-specific T cells, induce the differentiation of T cells, and regulate the function of T cells. The fusion protein of the present invention has the function of significantly increasing the tumor therapeutic effect of anti-PD-1 antibodies, and has broad medical treatment prospect.

Description

technical field [0001] The present invention generally relates to the field of bioengineering, and in particular relates to a fusion protein targeting antigen-specific T cells to induce their differentiation and enhance their effector functions. Background technique [0002] The role of the immune system is to enable the body to respond effectively to pathogens. T cells play a key role in this. Normal cells become malignant and become cancer cells, which can be recognized by the body's immune system to kill and eliminate them. The immune cells that can kill and eliminate growing tumors in the body are mainly T lymphocytes. After T lymphocytes recognize tumor antigens, they are activated, undergo massive expansion, and differentiate into effector T cells, which reach the tumor site and attack tumor cells. However, during the long-term evolution of tumor cells, various mechanisms have been developed to prevent the attack of immune cells. For example, tumor cells highly expre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K19/00C12N15/62A61K39/395A61P35/00
CPCC07K16/2818C07K14/54A61P35/00C07K2319/33C07K2317/76A61K2039/505
Inventor 王盛典李颖丛艳妮
Owner 乘典(苏州)生物医药有限公司