Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification

A compound, cholecalciferol technology, applied in biochemical equipment and methods, active ingredients of heterocyclic compounds, active ingredients of hydroxy compounds, etc., can solve the problems of limited treatment options, disease and disability, etc.

Inactive Publication Date: 2020-05-01
NOSTOPHARMA LLC
View PDF53 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, treatment options are very limited, and these disorders are often severely disabling

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification
  • Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification
  • Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0071] This example relates to the effect of certain combinations of compounds on the osteogenic differentiation of mesenchymal stem cells and bone marrow stromal cells.

[0072] method

[0073] Mesenchymal Stem Cell Isolation : Isolation of bone marrow stromal cells from 6- to 8-week-old wild-type mice. Dissect the femur and tibia from the surrounding tissue. The epiphyseal growth plate was removed and bone marrow was collected by flushing with a 25G needle with modified essential medium (MEM) containing 100 U / ml penicillin, 100 μg / ml streptomycin and 10% fetal bovine serum. Single-cell suspensions were prepared by passing cell pellets through an 18G needle followed by filtration through a 70-μm cell strainer.

[0074] Targets osteogenesis-initiating cells : An aliquot of cells was diluted 1:1 with 0.04% trypan blue in PBS, and live cells were plated 2 x 10 6 cells / cm 2The density was plated in 35-mm dishes, and exposed to recombinant mouse prolactin (PRL) (1 ng / ml)...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention is directed to compositions and methods for the prevention or treatment of treatment of heterotopic ossification, vascular calcification, or pathologic calcification.

Description

[0001] field of invention [0002] The present invention relates to a method of preventing or treating heterotopic ossification and other forms of pathological calcification in a patient by administering a pharmaceutical combination comprising: a) an antagonist of the Hedgehog signaling pathway; b) vitamin D. cholecalciferol or vitamin D analogs; and / or c) statins. The invention also includes pharmaceutical compositions administered to a patient while performing these methods. The invention also relates to the use of vitamin D, cholecalciferol or vitamin D analogs in the absence of Hh pathway antagonists or statins; and in the absence of Hh pathway antagonists, vitamin D, cholecalciferol or vitamin D analogs Methods of treatment or prevention using statins. [0003] Background of the invention [0004] Heterotopic ossification (HO) is characterized by the formation of heterotopic bone in soft tissue, such as fibrous tissue adjacent to a joint. Heterotopic ossification is mos...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K9/20A61K9/48A61K31/015A61K31/045A61K31/047A61K31/593A61K33/36A61K39/395A61K45/06
CPCC12N5/0663C12N2500/05C12N2500/38C12N2501/315C12N2501/36C12N2501/41C12N2501/999C12N2506/1353A61K45/06A61K31/22A61K31/366A61K31/40A61K31/404A61K31/4418A61K31/47A61K31/505A61K31/593C12N5/0654A61P19/08A61K2300/00A23L33/155A61L2400/02
Inventor 叶卡捷琳娜·韦尔-黄
Owner NOSTOPHARMA LLC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com