Rheumatoid arthritis scoring system based on multi-mode photoacoustic/ultrasonic imaging and application thereof
A rheumatoid, ultrasonic imaging technology, applied in the field of medical diagnosis, can solve the problems of clinical use limitation, high cost, large volume of PAT equipment, etc., and achieve the effect of simple and easy implementation and calculation process
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Embodiment 1
[0054] Example 1 Construction of Multimodal Photoacoustic / Ultrasonic Imaging System
[0055] 1. Data analysis and image acquisition
[0056] (1) Inspection procedure
[0057] Select clinically dominant MCP 2, MTP 3, PIP 2, PIP 3, MTP 2, MTP 5 and wrist joints for multimodal imaging. Prepare a white flat surface for the patient and place it on the table next to the imaging system. The probe is placed on the dorsal side of the fingers, wrist, and toes with the gel in between. First, traditional ultrasound scans of joints, including grayscale ultrasound, CDUS, and PDUS, are performed by an experienced ultrasound operator. Afterwards, PA / US imaging was performed on each joint by the same operator. By clipping the PA button on the operating screen, the laser is turned on and live PA and US imaging are played simultaneously. The depth to visualize the MCP and PIP joints was set at 2 cm, and the depth at the wrist was 2.5-3 cm. During a PA scan, the first part of the screen can...
Embodiment 2
[0088] Example 2. Scoring system for rheumatoid arthritis based on multimodal photoacoustic / ultrasound imaging
[0089] Such as image 3 as shown,
[0090] A scoring system for rheumatoid arthritis based on multimodal photoacoustic ultrasound imaging, including an information collection module, an information analysis module, and an output module,
[0091] The information collection module uses photoacoustic / ultrasound dual-modal imaging to collect image information of joints in vitro, so as to obtain image information of local inflammatory areas of rheumatoid joints;
[0092] The information analysis module classifies and calculates the collected image information to obtain the characteristic parameters of the image;
[0093] The judgment output module judges the disease activity of the rheumatoid arthritis patient and outputs the data in combination with the characteristic parameters of the image.
[0094] The information analysis module includes a semi-quantitative scori...
Embodiment 3
[0098] Embodiment 3, scoring application example
[0099] In April 2019, a 45-year-old female patient clinically diagnosed with RA was selected for multimodal imaging examination (the first). A total of 7 joints on the clinically obvious side of the patient were examined. There was no obvious blood flow signal in the MTP2, MTP3, MCP2, MCP3, PIP2, and PIP3 joint synovium, tendon sheath, and PD / PA in the surrounding area, and the imaging findings of the wrist joint were as follows: Figure 5 shown. The wrist joint synovium was obviously thickened, and color Doppler (PD) showed blood flow signals in the thickened area. Both sonographers scored 2 points. In the images of two wavelengths of photoacoustic (PA), more signals were selected The 830nm image of the patient was evaluated, and both doctors scored 3 points. The patient's multimodal imaging color Doppler (PD) total score was 2 points, and the photoacoustic (PA) total score was 3 points, and the blood flow signal Divided i...
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