Novel application of gastrodin

Abstract

The invention provides novel application of gastrodin. Application comprises application of the gastrodin in resistance to brain injury. It is found through experiments that the gastrodin can significantly enhance protection of nervous systems, and the action mechanism of the gastrodin is that the gastrodin can inhibit activated-microglial-cell-mediated activation of astrocytes, can reduce proteinexpression of inflammatory factors (TNF-alpha and iNOS), ACE, AT1 and NOX2 in the reactive astrocytes, and can promote up-regulation of SirT3, so as to achieve a neuroprotection effect; moreover, when AT1 receptor blocker-azilsartan and the gastrodin are applied in cooperation, expression of the NOX2 can be effectively reduced more, generation of the iNOS is reduced, and expression of the SirT3 is promoted at the same time to achieve a brain protection effect; meanwhile, the gastrodin promotes release of the astrocytes of a large number of neurotrophins of BDNF and IGF-1 more in the presenceof the microglial cells, so that the protection effect on the nervous systems is further enhanced; and it is proven that the gastrodin has good neuroprotection effect and brain protection effect, andhas potential clinical application prospects.

Description

【Technical field】 [0001] The invention relates to the technical field of medicine, in particular to a new application of gastrodin. 【Background technique】 [0002] Activated astrocytes are involved in many CNS diseases. Infection, neurodegenerative diseases, ischemia and hypoxia, etc. will lead to the activation and excessive proliferation of astrocytes, which play a dual role of protection and damage to the CNS. On the one hand, in the early stage of CNS injury, infection or disease, activated astrocytes release a large number of neurotrophic factors (neurotrophin, NT), including brain-derived neurotrophic factor (brain-derived neurotrophic factor, BDNF), neurotrophic factor 3 (neurotrophin, NT3), insulin-like growth factor-1 (insulin like growth factor-1, IGF-1), promote axon growth and neuron survival, repair local tissues, and maintain internal environment homeostasis. On the other hand, under pathological conditions, excessive activation of astrocytes can increase the...

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