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Drug sustained-release gel for treating ocular surface diseases and preparation method of drug sustained-release gel

A slow-release drug technology, applied in the field of medicine, can solve the problems of inconvenient continuous drug administration, poor effect of external eye diseases, and affecting the vision of patients, so as to achieve good drug slow-release performance, good therapeutic effect, and strong action force. enhanced effect

Active Publication Date: 2020-05-22
常州晶丽光学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the coating-type medicament is inconvenient for the patient to administer continuously for a certain period of time because it will affect the vision of the patient, and the effect for treating external eye diseases is not very good.

Method used

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  • Drug sustained-release gel for treating ocular surface diseases and preparation method of drug sustained-release gel
  • Drug sustained-release gel for treating ocular surface diseases and preparation method of drug sustained-release gel
  • Drug sustained-release gel for treating ocular surface diseases and preparation method of drug sustained-release gel

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Using the preparation method of the present invention to prepare a drug sustained-release silicon-free contact lens comprises the following steps:

[0028] S1: The configuration of the reaction raw material mixture, according to the initial molar ratio [HEMA] 0: [MAA] 0 :[EGDMA] 0 :[CETP] 0 :[AIBN] 0 :[PA] 0 =800:20:14:1:0.5:5 EGDMA, MAA, CETP and PA were dissolved in 3mL of HEMA respectively, and then the initiator AIBN was added to the mixed solution for dissolution to obtain the reaction raw material mixed solution;

[0029] S2: Preparation of drug slow-release gel, the reaction raw material mixture prepared in step S1 is deaerated by liquid nitrogen freezing-thawing 3 to 5 times, and then the deoxygenated reaction raw material mixture is placed in the solidification and molding of contact lenses In the mold, put the mold in an oven, under a nitrogen atmosphere, control the reaction temperature at 60°C, and react for 50 hours to obtain the drug sustained-release...

Embodiment 2

[0034] Using the preparation method of the present invention to prepare a drug sustained-release silicon-containing contact lens comprises the following steps:

[0035] S1: The configuration of the reaction raw material mixture, according to the initial molar ratio [HEMA] 0 :[MAA] 0 :[TEOSPMA] 0 :[MBA] 0 :[CPDB] 0 :[AIBN]0 :[DA] 0 =780:20:20:14:1:0.5:5 MBA, MAA, TEOSPMA, CPDB and DA were dissolved in 3mL of HEMA respectively, then the initiator AIBN was added to the mixed solution for dissolution to obtain the reaction raw material mixed solution;

[0036] S2: Preparation of drug slow-release gel, the reaction raw material mixture prepared in step S1 is deaerated by liquid nitrogen freezing-thawing 3 to 5 times, and then the deoxygenated reaction raw material mixture is placed in the solidification and molding of contact lenses In the mold, put the mold in an oven, under an argon atmosphere, control the reaction temperature at 65°C, and react for 40 hours to obtain the dr...

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Abstract

The present invention discloses a drug sustained-release gel for treating ocular surface diseases and a preparation method of the drug sustained-release gel. A reversible addition-fragmentation chaintransfer (RAFT) polymerization method is used to prepare monomers, a crosslinking agent, a RAFT reagent, an initiator and anti-inflammatory drugs into the hydrogel loaded with the anti-inflammatory drugs at a time. The hydrogel can be used as a soft contact lens for treating the ocular surface diseases. Compared with traditional ocular surface coating methods, the soft contact lens can fit the cornea well, thus the gel controllably achieves sustained-release of the drugs, achieves a purpose of non-invasive continuous sustained-release drug delivery and is also high in drug delivery efficiency.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a drug slow-release gel for treating ocular surface diseases and a preparation method thereof. Background technique [0002] External eye diseases mainly occur in the conjunctiva and cornea, and infectious external eye diseases are most common in infectious conjunctivitis and infectious keratitis. Even endanger the patient's eyesight. Especially in developing countries, bacterial keratitis is often the leading cause of corneal blindness. Eye drops are commonly used medicines for the treatment of external eye diseases. However, after eye drops are dripped into the eyes, they run faster on the cornea. Delivery effectiveness on corneal tissue. Generally, the amount of medicinal solution that really plays a role on the corneal surface only accounts for about 5% of the total amount of medicinal solution, and the medicinal solution inhaled by the patient is not only was...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K45/00A61K31/573A61K47/32A61P27/02A61P5/38C08F220/20C08F220/06C08F230/08
CPCA61K9/06A61K9/0048A61K45/00A61K31/573A61K47/32A61P27/02A61P5/38C08F220/20C08F220/06C08F230/08
Inventor 程振平
Owner 常州晶丽光学科技有限公司