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Compound composition preparation as well as preparation method and application thereof in skin inflammation

A composite composition and derivative technology, applied in skin diseases, drug combinations, anti-inflammatory agents, etc., can solve the problems of aggravated disease, difficult to cure, and recurrent disease, and achieve high safety, short treatment period, and good treatment effect of effect

Active Publication Date: 2020-05-22
WUHAN WORLDNER UNITED PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently such diseases are mainly treated with corticosteroids and immunosuppressants (tacrolimus, IL4 antibody, IgM antibody, etc.), but the recurrence rate is extremely high. recurrent, difficult to heal
[0003] In 2017, Sanofi Pharmaceuticals launched "Regeneron-IL4 Antibody" for the treatment of moderate to severe eczema (atopic dermatitis), combined with hormones, the effective rate was only 48%, and 2 cases have occurred during the use period death due to adverse reactions
[0004] In order to solve the defect of the single treatment plan for skin diseases using the principle of immunosuppression in the prior art, the present invention provides a compound nutritional composition based on the principle of skin barrier repair and its preparation method and application

Method used

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  • Compound composition preparation as well as preparation method and application thereof in skin inflammation
  • Compound composition preparation as well as preparation method and application thereof in skin inflammation
  • Compound composition preparation as well as preparation method and application thereof in skin inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Mix the following components uniformly to obtain composite composition 1: 40% nicotinamide ribose, 40% monoammonium glycyrrhizinate, 15% vitamin C magnesium phosphate, and 5% cyclic adenosine monophosphate, and the percentages are mass percentages.

Embodiment 2

[0034] Mix the following components uniformly to obtain composite composition 2: 30% nicotinamide mononucleotide, 20% disodium glycyrrhizinate, 49% sodium vitamin C phosphate, 1% cyclic adenosine monophosphate, the percentages are by mass percentage.

Embodiment 3

[0036] Mix the following components uniformly to obtain compound nutritional composition 3: 5% nicotinamide mononucleotide, 50% disodium glycyrrhizinate, 15% sodium vitamin C phosphate, 30% adenosine cyclophosphate meglumine, the Percentages are mass percentages.

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Abstract

The invention relates to a compound nutrient composition based on a skin barrier repair principle as well as a preparation method and application of the compound nutrient composition. The compound composition plays a skin disease treatment role by repairing skin barriers based on no inhibition of body immunity and is good in treatment effect, short in treatment period and high in safety.

Description

technical field [0001] The invention relates to a composite composition preparation, a preparation method thereof and an application in skin inflammation. Background technique [0002] Common skin diseases are mainly caused by immune activation and excessive inflammation. It can lead to many skin diseases, including atopic dermatitis, psoriasis, telangiectasia, hormone-dependent dermatitis, diabetic foot, AIDS-related skin and mucous membrane inflammation, etc., bringing many physical discomfort and psychological barriers to patients. Currently such diseases are mainly treated with corticosteroids and immunosuppressants (tacrolimus, IL4 antibody, IgM antibody, etc.), but the recurrence rate is extremely high. Recurrent outbreaks are difficult to cure. [0003] In 2017, Sanofi Pharmaceuticals launched "Regeneron-IL4 Antibody" for the treatment of moderate to severe eczema (atopic dermatitis), combined with hormones, the effective rate was only 48%, and 2 cases have occurred...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K31/7084A61K31/7076A61P17/00A61P17/06A61P17/02A61P29/00A61K31/375A61K31/455A61K31/56
CPCA61K31/7084A61K31/7076A61K31/375A61K31/56A61K31/704A61K31/455A61P17/00A61P17/06A61P17/02A61P29/00A61K2300/00
Inventor 丁虹程雅红汤柳李晓磊杜思达
Owner WUHAN WORLDNER UNITED PHARMA
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