Novel compound and preparation method and application thereof

A compound and a new type of technology, applied in the field of new compounds and their preparation, can solve the problems of many effective active ingredients, ambiguous detoxification mechanism, scientific, standardized and internationalization of restricted traditional Chinese medicine detoxification compound

Pending Publication Date: 2020-06-12
GUANGXI JIUFU BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the traditional Chinese medicines currently used for detoxification treatment are compound preparations evolved on the basis of traditional ancient prescriptions for detoxification, in which there are many and complex active ingredients, the detoxification mechanism is relatively vague, and there are relatively few studies on pharmacology and toxicology, which limits the The Scientificization, Standardization and Internationalization of Traditional Chinese Drug Rehabilitation Compound

Method used

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  • Novel compound and preparation method and application thereof
  • Novel compound and preparation method and application thereof
  • Novel compound and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] The invention provides a novel compound, its specific structure is:

[0058]

[0059] The specific information of the compound is as follows:

[0060] (1) The compound is named "3,12,13-triacetyl slugol", and its English name is: 3,12,13-threeacetyl limaxol A.

[0061] (2) Chiral C configuration in the compound: C3, R; C6, S; C7, S; C10, S; C11, R; C12, R; C13, R; C14, R; C15, S; C18, S; C19, S; C22, R., its crystal structure is shown in figure 1 .

[0062] (3) Its physical and chemical properties and spectral data:

[0063] ①Molecular formula: C 36 h 58 o 10 ; Molecular weight 650.

[0064] ②State: white needle crystal.

[0065] ③Melting point: 228~229℃.

[0066] ④Solubility: Insoluble in water, rarely soluble in acid and alkali, easily soluble in ethyl acetate and acetic acid, soluble in methanol, ethanol, acetone, and chloroform.

[0067] ⑤NMR carbon (C) spectrum data, NMR hydrogen (H) spectrum data, see Table 1 and Figure 2-Figure 5 .

[0068] Table ...

Embodiment 2

[0076] A kind of preparation method of novel compound (supercritical CO 2 extraction method), including the following steps:

[0077] R1. Take the slugs, clean them, remove impurities, crush them to 30 mesh, and set aside;

[0078] R2. Weigh 50kg of slug powder and put it into supercritical CO 2 Extraction is carried out in the extractor, the extraction conditions are pressure 20KPa, temperature 60°C, flow rate 400-500PV, extraction time 3h, release the extract after the extraction is completed, and obtain 2.9kg of ointment-like extract, which is ready for use;

[0079] R3. Take the above extract, add tea seed oil according to the weight ratio "extract: tea seed oil = 2:1", that is, extract 2.9kg, tea seed oil 1.45kg, put them together in a mixing tank, 60°C Heat and stir evenly, let stand for 7 days, precipitate out, filter to obtain 198g of precipitate, add petroleum ether to heat and wash the precipitate 3 times, each time 200ml, dry, and obtain 123g of precipitate;

[0...

Embodiment 3

[0082] A kind of preparation method of novel compound (supercritical CO 2 extraction method), including the following steps:

[0083] R1. Take the slugs, clean them, remove impurities, crush them to 20 mesh, and set aside;

[0084] R2. Weigh 60kg of slug powder and put it into supercritical CO 2 Extraction is carried out in the extractor, the extraction conditions are pressure 25KPa, temperature 65°C, flow rate 400-500PV, extraction time 4h, release the extract after the extraction is completed, and obtain 3.5kg of oily extract, which is set aside;

[0085] R3. Take the extract, add soybean oil according to the weight ratio "extract: soybean oil = 4:2", that is, extract 3.5kg, soybean oil 1.75kg, put them together in a mixing tank, heat at 65°C and stir evenly , let it cool, let it stand for 8 days, filtered to obtain 235g of precipitate, washed 3 times with n-hexane for each amount of 300ml, and dried to obtain 151g of precipitate;

[0086] R4. Take the precipitate, add 50...

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Abstract

The invention discloses a novel compound as well as a preparation method and application thereof. The novel compound disclosed by the invention is extracted and separated from slugs, the compound hasa remarkable physiologic and psychological dependent detoxification or drug rehabilitation effect, and pharmacological tests prove that the compound has an obvious inhibition effect on withdrawal jumpsymptoms of morphine dependent animals after intragastric administration for 1 hour, and still has an inhibition trend after 3 hours. The compound can be used for preparing medicines, health-care foods and foods for detoxification, drug rehabilitation or similar drug-dependent treatment, and has potential application value.

Description

technical field [0001] The invention belongs to the field of biomedical chemistry, and specifically relates to a novel compound and its preparation method and application. Background technique [0002] Drugs refer to drugs that are used repeatedly and continuously for non-medical purposes to produce dependence (that is, addiction). There are more and more drug addicts, and the age is getting younger and younger. The number of drug addicts in my country alone is more than 14 million, and the number of drug addicts in the world reaches 200-400 million. The harm of drugs to the world is becoming more and more serious, and the types of drugs are becoming more and more diverse, from opium and marijuana to heroin, K powder, methamphetamine and so on. The proliferation of drugs will directly endanger people's physical and mental health, and pose a huge threat to economic development and social progress. [0003] Drug rehabilitation refers to drug addicts getting rid of the bad ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/08A61P25/30A23L33/10
CPCC07D493/08A61P25/30A23L33/10A23V2002/00A23V2200/334A23V2250/204A61P25/36Y02P20/54A61K31/35A61K35/618A23V2200/322A23V2250/30A61K31/618C07D493/18
Inventor 阮俊
Owner GUANGXI JIUFU BIOTECH CO LTD
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