Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Stent, preparation method thereof and application thereof in breast cancer treatment and bone repair

A breast cancer and scaffold technology, applied in the field of medical devices, can solve the problems of chemotherapy drug toxicity and drug resistance, and achieve the effect of tumor treatment and good biocompatibility

Inactive Publication Date: 2020-06-19
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
View PDF11 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chemotherapy alone has many adverse reports, such as: chemotherapy drug toxicity and drug resistance

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Stent, preparation method thereof and application thereof in breast cancer treatment and bone repair
  • Stent, preparation method thereof and application thereof in breast cancer treatment and bone repair
  • Stent, preparation method thereof and application thereof in breast cancer treatment and bone repair

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Mix calcium silicate powder and 10w / w%~15w / w% polyvinyl alcohol aqueous solution according to the mass ratio of 0.8~1.5 to form a 3D printing slurry, and use extrusion 3D printing technology to print out the frame body, after 900℃~1600℃ Calcined for 3 hours, and then loaded niobium carbide nanosheets on the surface of the frame, see figure 1 .

Embodiment 2

[0025] The scaffold prepared in Example 1 was used for killing experiments on breast cancer cells (human breast cancer cells MDA-MB-231, Cell Bank of Chinese Academy of Sciences). The grouping is as follows:

[0026] (1) Control group: no treatment;

[0027] (2) Scaffold group: co-culture the scaffold and cells, and use 1.5W / cm 2 808nm laser irradiation for 5 minutes.

[0028] After continuing to culture for 48 hours, one-tenth of the total volume of CCK-8 solution was added to each well. Continue incubation for 2 hours in the cell culture incubator. The absorbance was measured at 450nm, and the obtained absorbance value was corrected and standardized by the absorbance value of the blank well, and the obtained results were as follows figure 2 shown. Compared with the control group, the scaffold prepared in Example 1 has a significant killing effect on breast cancer cells.

Embodiment 3

[0030] The scaffold prepared in Example 1 is used for the treatment of breast cancer bone metastasis and bone repair. The grouping is as follows:

[0031] (1) Control group: no treatment;

[0032] (2) Stent group: the stent was implanted into the skull defect of SD rats.

[0033] After 9 weeks of normal feeding, the rats were taken to evaluate the amount of new bone formation. The results were as follows: image 3 shown. Compared with the control group, the scaffold prepared in Example 1 can significantly promote the repair of the defective skull.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
elastic modulusaaaaaaaaaa
porosityaaaaaaaaaa
Login to View More

Abstract

The invention provides a stent. The stent comprises calcium silicate, polyvinyl alcohol and niobium carbide. The stent has good biocompatibility, can be made into various shapes by a 3D printing technology, can meet the implantation and treatment requirements of various tissues in a personalized manner, has photothermal characteristics, can realize tumor treatment, and also has effects on the treatment of breast cancer bone metastasis and bone repair.

Description

technical field [0001] The invention relates to a medical device, in particular to a bracket, which is manufactured in 3D and implanted in the body, and has the functions of treating breast cancer and bone repair. Background technique [0002] According to the data of the World Health Organization in 2018, breast cancer accounts for the second (11.6%) of new tumors in the world and the fifth (6.6%) of the deaths caused by tumors. It is worth noting that Asians accounted for 43.6% of the total incidence and 49.6% of the total mortality. Although in the past ten years, many methods have been used for the treatment of breast cancer according to the diagnosis time of breast cancer, such as: surgical resection, radiotherapy, chemotherapy, hormone and biological therapy, but there is still room for improvement in clinical effect. Therefore, the introduction of new and effective breast cancer treatment modalities is urgently needed and necessary. [0003] Chemotherapy alone has m...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/02A61L27/30A61L27/16A61L27/54A61K41/00A61P35/00A61P35/04A61P15/14B33Y70/10
CPCA61K41/0052A61L27/025A61L27/16A61L27/306A61L27/54A61L2300/102A61L2300/416A61P15/14A61P35/00A61P35/04B33Y70/00C08L29/04
Inventor 贺超郝永强王磊
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com