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Colchicine tablet and preparation method thereof

A colchicine tablet and colchicine technology, applied in the field of medicine, can solve the problem that the cumulative release rate cannot meet the requirements of the Pharmacopoeia, and achieve the effect of less impact on the body's physiological functions, recovery of enzyme activity, and fewer adverse reactions

Inactive Publication Date: 2020-06-23
广东彼迪药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some defects in the existing patented technology, such as: (1) adopting osmotic pump technology to obtain constant drug release in vitro, but limited by the solubility and dosage of colchicine itself, its cumulative release rate cannot meet the requirements of the Pharmacopoeia

Method used

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  • Colchicine tablet and preparation method thereof
  • Colchicine tablet and preparation method thereof
  • Colchicine tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020]

[0021]

[0022] Preparation Process:

[0023] The prescription quantity takes colchicine and vonoprazan fumarate passed through an 80-mesh sieve, mixes them with the prescription quantity of silicified microcrystalline cellulose, sodium carboxymethyl starch, and magnesium stearate, and compresses them into tablets.

Embodiment 2

[0025]

[0026] Preparation Process:

[0027] The prescription quantity takes colchicine and vornoprazan fumarate passed through an 80-mesh sieve, mixes them with the prescription quantity of microcrystalline cellulose, crospovidone, and magnesium stearate, and compresses them into tablets.

Embodiment 3

[0029]

[0030] Preparation Process:

[0031] The prescription quantity takes colchicine and vonoprazan fumarate through a 100-mesh sieve, mixes them with the prescription quantity of microcrystalline cellulose, lactose, sodium carboxymethyl starch, and magnesium stearate, and compresses them into tablets.

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PUM

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Abstract

The invention discloses a colchicine tablet. The colchicine tablet is prepared by the following method, and the method comprises the steps of mixing colchicine and vonoprazan fumarate with pharmaceutically acceptable auxiliary materials, and carrying out tabletting. Animal experiments show that the colchicine tablet prepared by the method has no obvious gastrointestinal reaction and good animal compliance.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a colchicine tablet and a preparation method thereof. Background technique [0002] Colchicine is a well-known drug that can be used in the treatment of gout and anti-cancer fields. Colchicine can inhibit the infiltration and phagocytosis of granulocytes during gout attacks, and has selective anti-inflammatory effects on acute gouty arthritis. It is the most effective drug for the treatment of acute gout; in terms of anti-cancer, it can treat leukemia, breast cancer, etc. by inhibiting cell mitosis. In recent years, it has been discovered in the academic field that colchicine can also be used to treat liver cirrhosis. Colchicine has serious side effects, mainly including gastrointestinal reactions, liver damage, kidney damage, bone marrow toxicity, hair loss, mental depression, anorexia, numbness of hands and feet, etc. Hemorrhagic gastroenteritis, nausea, vomiting,...

Claims

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Application Information

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IPC IPC(8): A61K31/4439A61K31/165A61K9/20A61P19/06A61P1/04
CPCA61K31/4439A61K31/165A61K9/2059A61P19/06A61P1/04A61K2300/00
Inventor 刘小兰杨松明
Owner 广东彼迪药业有限公司