Biosensor used for detecting whole-cell bacteria and biosensor group comprising the biosensor

Abstract

The invention relates to a biosensor mainly comprising a field effect transistor and used for detecting whole-cell bacteria and a biosensor group comprising the biosensor. The invention discloses a field effect transistor-based biosensor for detecting whole-cell bacteria. The biosensor comprises a source electrode, a drain electrode and a biosensing component arranged between the source electrodeand the drain electrode, the biosensing component comprises at least one semiconductor wire, a surface modification layer and a plurality of detection elements. The semiconductor wire serves as a semiconductor channel connecting the source and the drain, and has a length to allow the biosensing member to capture whole-cell bacteria. A field effect transistor-based biosensor set including the biosensor is also disclosed.

Description

technical field [0001] This application claims priority to US Provisional Application Serial No. 62 / 793,974, filed January 18, 2019, the contents of which are hereby incorporated by reference. [0002] The present invention relates to a field-effect transistor-based biosensor, in particular to a field-effect transistor-based biosensor for detecting whole-cell bacteria. The present invention also relates to a field-effect transistor-based biosensor set, which includes the field-effect transistor-based biosensor. Background technique [0003] Detection of bacterial pathogens is of paramount importance in various fields, including food and pharmaceutical industries, public health, social security, and more. Contamination of pathogenic bacteria in food products, medical supplies or water resources can have serious consequences. For example, if the human population is exposed to contamination sources such as bacterial pathogens, it may lead to outbreaks of bacterial infections,...

AI Technical Summary

Problems solved by technology

Although these traditional detection methods allow detection of a single bacterium, the detected signal must be amplified

Traditional detection methods also require culturing single cells into cell colonies, which is time-consuming and usually takes up to 72 hours

Furthermore, traditional detection methods are limited to specialized laboratories and require trained personnel

In addition, to shorten detection time and simplify assay procedures, direct detection of bacterial pathogens in whole cells is preferred over detection of their biomolecules, which require prolonged assay time and thus costly additional purification steps

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