Pharmaceutical preparation containing tiotropium bromide and arformoterol

Abstract

The invention provides a pharmaceutical preparation containing tiotropium bromide and arformoterol. The pharmaceutical preparation comprises tiotropium bromide or hydrate thereof, and the administration range is 2.5-200 [mu] g; the administration range of the arformoterol or the salt thereof is 4-200 [mu] g; the tiotropium bromide acts on a muscarinic receptor on bronchial smooth muscle, can inhibit cholinergic effect of acetylcholine released at the tail end of parasympathetic nerve, blocks muscular tension, and generates bronchiectasis; the arformoterol acts on beta 2-receptors on airway smooth muscle cell membranes, so that airway smooth muscles are relaxed, release of mast cells, basophilic cell degranulation and media is reduced, permeability of capillaries is reduced, and swing of airway epithelium cilia is increased; when the two medicines are combined for use, the bronchial relaxation effect is achieved through different mechanisms, and on the important clinical indexes of reducing acute exacerbation of a patient suffering from chronic obstructive pulmonary disease, reducing the all-cause mortality, improving the lung function of the patient suffering from chronic obstructive pulmonary disease, improving the living quality and the like, the two medicines are combined for use, so that the application range of the pharmaceutical preparation for indications is wider than that of a single medicine.

Description

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AI Technical Summary

Benefits of technology

This patented technology can help improve breathing by reducing symptoms like difficulty swallowing or shortness of breath during exercise due to an abnormal increase in intrabral pressure caused by increased activity levels such as smoking cigarettes or alcohol consumption. It also helps treat asthmatic attacks that are associated with high blood chloride concentration (hyperoxygenated condition). By combining these three agents together it may be possible for them to work synergistically without causing any side effects at once.

Problems solved by technology

This patented technical problem addressed in this patents relates to improving treatment options for individuals who suffer from various conditions caused by lung diseases like COPD due to their ability to block up certain parts of your lungs' blood flow while also having fewer symptoms than usual.

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