Group of multi-index combined detection colloidal gold test strips for early esophageal cancer screening

A technology for colloidal gold test strips and esophageal cancer, which is applied in measurement devices, instruments, disease diagnosis, etc., can solve problems such as low detection efficiency, poor compliance, and affect detection efficiency, and achieves high detection success rate, low cost, and reduced death. rate effect

Active Publication Date: 2020-08-21
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first three methods are likely to cause discomfort to the general population, resulting in poor patient compliance, while the colloidal gold detection test paper has the characteristics of convenient, economical, non-invasive, and timely reflection of changes in the condition.
However, the existing colloidal gold detection test paper can usually only detect one indicator, so that in the process of detecting multiple indicators, the detection efficiency is relatively low, which seriously affects the detection efficiency. A new multi-index joint detection colloidal gold test is urgently needed. note

Method used

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  • Group of multi-index combined detection colloidal gold test strips for early esophageal cancer screening
  • Group of multi-index combined detection colloidal gold test strips for early esophageal cancer screening
  • Group of multi-index combined detection colloidal gold test strips for early esophageal cancer screening

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Colloidal gold test strips for early screening of esophageal cancer

[0029] 1. Structural composition of colloidal gold test strips

[0030] A colloidal gold test strip for early esophageal cancer screening, such as figure 1 As shown, including the PVC bottom plate, the sample pad, gold standard pad, nitrocellulose membrane and water-absorbing pad are sequentially laid on the PVC bottom plate along the length direction. The gold standard pad is pressed between the sample pad and the nitrocellulose membrane, that is, the gold standard One end of the pad overlaps under the sample pad, and the other end overlaps above the nitrocellulose membrane; the beginning of the absorbent pad overlaps the end of the nitrocellulose membrane; four test lines (T1, T2) are sequentially arranged on the nitrocellulose membrane , T3, T4) and a control line (C line), the T1 line is set on the end of the nitrocellulose membrane close to the gold standard pad, and the C line is set ...

Embodiment 2

[0063] Example 2 Analysis of the effectiveness of colloidal gold test strips for early esophageal cancer screening

[0064] Serum samples of patients with early esophageal cancer and healthy subjects are tested by using the test strip of the present invention to evaluate and analyze the effectiveness analysis of the test strip of the present invention for early esophageal cancer screening.

[0065] Serum Sample Collection

[0066] Collected 255 cases of healthy persons from the physical examination center of the cooperative hospital of the inventor's laboratory, and no tumor-related lesions were found in the selected healthy persons. At the same time, the same number of patients with early stage (stage 0+stage I) esophageal cancer from the cooperative hospitals of our laboratory were collected. The selected patients with early stage esophageal cancer were those diagnosed by pathological sections, and none of them had received radiotherapy or chemotherapy. .

[0067]Take 5ml ...

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Abstract

The invention belongs to the technical field of bioengineering and biomedicines, particularly relates to the field of oncology, and more particularly relates to a group of multi-index combined detection colloidal gold test strips for early esophageal cancer screening. According to the colloidal gold test strips, specific detection reagents of four antigens, namely KDM2A, SLC2A3, HOXC13 and TMEM132C, are combined to detect the early esophageal cancer; the detection sensitivity is as high as 93.7%, and the specificity reaches 71.4%, that is, the colloidal gold test strips provided by the invention have high sensitivity and specificity for early esophageal cancer detection, and are suitable for large-scale screening of asymptomatic people in esophageal cancer high-incidence areas.

Description

technical field [0001] The invention belongs to the technical fields of bioengineering and biomedicine, specifically relates to the field of oncology, and more specifically relates to a set of multi-index joint detection colloidal gold test strips for early esophageal cancer screening. Background technique [0002] Since the 20th century, the incidence and mortality of esophageal cancer have been on the rise, and its geographical distribution is uneven. According to GLOBOCAN2018, there were 572,000 new cases of esophageal cancer worldwide, ranking sixth among malignant tumors; 509,000 deaths, ranking seventh among malignant tumors. China is one of the countries with a high incidence of esophageal cancer. National statistics show that the incidence rate of esophageal cancer in my country in 2018 was 18.85 / 100,000, ranking fifth among malignant tumors, and the mortality rate was 14.11 / 100,000, ranking fourth among malignant tumor deaths. Moreover, 90% of esophageal cancer in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574G01N33/577G01N33/558
CPCG01N33/558G01N33/57407G01N33/57488G01N33/577G01N2333/47G01N2800/60
Inventor 宋昕孟超龙王立东赵学科韩文莉吉佳佳李贝范宗民韩雪娜王苒杨道科
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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