Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Urethral catheter and preparation method thereof

A catheter and tube body technology, applied in catheters, pharmaceutical formulations, coatings and other directions, can solve problems such as damage and beneficial cell damage, and achieve the effects of convenient and simple operation, reducing friction and avoiding damage

Active Publication Date: 2020-09-01
JIANGSU BIOSURF BIOTECH CO LTD
View PDF11 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method of using ultraviolet light to sterilize bacteria is likely to cause unknown damage to the beneficial cells on the surface of the urethra, resulting in greater damage

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Urethral catheter and preparation method thereof
  • Urethral catheter and preparation method thereof
  • Urethral catheter and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0089] Preparation method of urinary catheter

[0090] The present invention also provides a preparation method of a urinary catheter, comprising:

[0091] (i) forming the coating composition on the surface of the catheter body and curing it under light;

[0092] (ii) The heparin and chitosan are alternately self-assembled on the outer surface of the coating to form a heparin and chitosan bilayer, and the alternate self-assembly is repeated n times to form n layers of heparin and chitosan bimolecules layer, where n≥1.

[0093] Wherein, the coating composition is formed on the surface of the urinary catheter body by one or more methods of brushing, dipping, spraying, pouring and scraping.

[0094] Wherein, the light source used during illumination includes any one of UV light source, visible light source, and infrared light source; preferably, the light source is a UV light source and a visible light source; more preferably a UV light source. Preferably, the UV light inten...

Embodiment 1

[0100] Step 1: Synthesis of water-soluble photosensitive monomer

[0101] Weigh 22.4g (100mmol) 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, 10.6g (105mmol) triethylamine and dissolve in 100mL dichloromethane and place in a 250mL flask and placed in an ice-water bath to fully dissolve. 9.1 mL of bromoacetyl bromide (21.1 g, 105 mmol) in dichloromethane was slowly added dropwise to the flask, and the dropwise addition was completed within 1 h. After reacting for 0.5 h under ice-bath conditions, the reaction was continued for 10 h at room temperature. After the reaction was completed, cool to room temperature and dissolve the crude product in dichloromethane, wash twice with saturated brine, hydrochloric acid (1M) and saturated sodium bicarbonate successively, dry over anhydrous magnesium sulfate, filter and spin dry the solvent, wash with acetic acid Ethyl ester and n-hexane were used as eluents, and after purification by column chromatography, 28.8g of 2-hydroxyl-...

Embodiment 2

[0126] The number of layers of the self-assembled bilayers of the five kinds of heparin and chitosan in the step of Example 1 was changed, and the other steps were the same as in Example 1. The lubricating properties of the samples were evaluated, and the results are shown in Table 3.

[0127] Table 3 Lubrication performance of urinary catheters with different layers of self-assembled layers

[0128]

[0129] It can be seen that the number of self-assembled bilayers of heparin and chitosan on the surface of the catheter does not have much influence on the lubricating properties of the catheter surface, and the catheter dipped in a lubricating coating can still maintain good performance. lubricating performance.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Thicknessaaaaaaaaaa
Strengthaaaaaaaaaa
Login to View More

Abstract

The invention relates to a urethral catheter and a preparation method thereof. The urethral catheter comprises a catheter body, a coating formed on the surface of the catheter body, and heparin and chitosan which are self-assembled on the outer surface of the coating layer by layer, wherein the coating is formed by a coating composition, and the coating composition comprises at least one photocurable polymer. According to the urethral catheter, the damage of the urethral catheter to the inner surface of the urethra can be avoided. Meanwhile, accumulation of crystals can be effectively inhibited, bacteria adhered to the surface of the urethral catheter and the wound surface of the urethra can be killed, and the risk of bacterial infection is reduced.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular to the field of urinary catheters with modified surfaces. Background technique [0002] The indwelling catheter method is a method of retaining the catheter in the bladder to drain urine after catheterization. It is widely used in severe patients after anesthesia or surgery, and is a commonly used invasive nursing operation in clinical practice. Catheters used in indwelling catheterization require higher performance than catheters for short-term use. The main reason is that indwelling catheters are prone to cause various complications in the body, such as catheter-associated urinary tract infection, bladder function damage, and crystal formation on the surface of catheters. [0003] The most typical problem of indwelling catheters is urinary tract infection. The insertion of catheters often causes damage to the urethral mucosa, destroys the natural barrier of the urethral mucosa, and...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L29/12A61L29/08A61L29/14A61L29/16
CPCA61L29/085A61L29/14A61L29/16A61L2400/10A61L2420/02A61L2420/08A61L2420/06C08L5/10C08L5/08C08L33/14
Inventor 李业雷杰华
Owner JIANGSU BIOSURF BIOTECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com