Composition for treating bladder cancer and preparation method thereof

A composition and technology for bladder cancer, applied in the field of medicine, can solve the problems of poor use feeling, easy generation of drug resistance, and insignificant effect in patients, achieve inhibition of proliferation, good anti-cancer activity and enrichment effect, and reduce damage to the body Effect

Inactive Publication Date: 2020-10-16
石小和
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the embodiments of the present invention is to provide a composition for treating bladder cancer, which aims to solve the technical problems that existing drugs for treating bladder cancer have large toxic and side effects, poor user experience, easy to develop drug resistance, and ineffective effects

Method used

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  • Composition for treating bladder cancer and preparation method thereof
  • Composition for treating bladder cancer and preparation method thereof
  • Composition for treating bladder cancer and preparation method thereof

Examples

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preparation example Construction

[0039] As a preferred embodiment, the preparation of the vinegar at least includes: soaking the raw materials with water, steaming and stewing the raw materials to obtain the raw materials to be fermented; Vinegar, frozen vinegar, and aging. Specifically, the preparation method of the vinegar includes the steps of: a) adding water to the raw material for infiltration to make it fully absorb water to obtain the infiltrated grain material; b) adding the grain material to the infiltrated grain material Water with a weight of 140% to 240%, stewing the material for 15min to 80min to obtain the raw material to be fermented; c) adding the famous wine strain Daqu with a weight of 20% to 70% of the grain raw material to the raw material to be fermented, and mixing , then adding 40% to 70% of the total weight of the grain raw material, fermenting at 28°C to 35°C for 15 to 730 days to obtain wine mash; d) adding 100% of the weight of the grain raw material to the wine mash ~ 300% grain ...

Embodiment 1

[0064] The embodiment of the present invention provides a composition for treating bladder cancer, which includes the following raw materials in parts by weight:

[0065] 400 parts of vinegar liquid, 5 parts of rehmannia root, 8 parts of astragalus, 3 parts of angelica, 8 parts of Lishui, 3 parts of Alisma, 4 parts of Chuanqiong, 4 parts of polyporus, 2 parts of leech, and 3 parts of Phellodendron chinensis.

[0066] Its specific preparation process is:

[0067] S10. Obtain the medicinal materials of Rehmannia glutinosa, Astragalus membranaceus, Angelica sinensis, Alisma sinensis, Alisma, Chuanqiong, Polyporus, leech and Cortex Phellodendri in the prescribed amount, wash the above medicinal materials, then dry them with a dryer and perform preliminary chopping with a mechanical rotary pulverizer , so that the particle size of the medicinal material is about 500 μm;

[0068] S20. Obtain the vinegar of the recipe, extract the coarse-grained medicinal materials with the vinegar,...

experiment example 1

[0077] Animal experiments examine the effect of the composition for treating bladder cancer prepared in Example 1 of the present invention on bladder cancer

[0078] 1. Experimental method

[0079] 1.1 Cell culture: Human bladder cancer cell line T24 was cultured in RPMI 1640 medium (containing 10% fetal bovine serum, 100 U / ml of penicillin and streptomycin), placed at 37°C, saturated humidity, 5% CO 2 The cells were cultured in a single layer in an incubator, and the medium was changed and passaged every two days. Collect T24 cells in the logarithmic growth phase, and adjust the cell concentration to 2×10 7 / ml

[0080] 1.2 Establishment and grouping of human bladder cancer xenograft model

[0081] After subcutaneously disinfecting the backs of nude mice weighing 15-20 g, each mouse was inoculated with 0.2 ml of cell suspension. After transplantation, the nude mice were kept in the SPF environment, and tumor nodules appeared at the inoculation site, and the texture was ha...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a composition for treating bladder cancer. The composition for treating bladder cancer comprises the components in percentage by weight: 80-100% of active component and 0-20% of auxiliary materials, and the particle size of the composition for treating bladder cancer is 20-100 nanometers. The active component comprises the following raw materials in parts by weight: 200-500 parts of vinegar, 5-10 parts of dried rehmannia root, 5-10 parts of astragalus root, 2-5 parts of radix angelicae sinensis, 5-10 parts of herba polygoni avicularis, 2-5 parts of rhizoma alismatis, 2-5 parts of rhizoma chuanxiong, 2-5 parts of Polyporus, 2-5 parts of leech and 2-5 parts of cortex phellodendri. The nano-level composition for treating bladder cancer can improve the growth microenvironment of bladder tumor, regulate tumor immune metabolism, inhibit tumor cell proliferation and metastasis, and regulate the occurrence and development of bladder tumor through the synergistic compatibility of active substances in the active component.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composition for treating bladder cancer and a preparation method thereof. Background technique [0002] Bladder cancer refers to malignant tumors that occur on the bladder mucosa. It is the most common malignant tumor with the highest incidence rate in the urinary system, and it is also one of the ten most common tumors in the whole body. Accounting for the first place in the incidence of genitourinary system tumors in my country, it seriously endangers human health, and its incidence is increasing year by year. Bladder cancer can occur at any age, even in children, and its incidence increases with age, with the highest incidence age being 50-70 years old. The incidence rate of bladder cancer in men is 3 to 4 times that of women. Bladder cancer is the fourth malignant tumor in men after prostate cancer, lung cancer and colorectal cancer. Bladder cancer has the ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61K36/899A61P35/00A61P35/04A61K31/19A61K35/62
CPCA61K31/19A61K35/62A61K36/07A61K36/232A61K36/236A61K36/481A61K36/704A61K36/756A61K36/804A61K36/884A61K36/899A61K2236/333A61P35/00A61P35/04A61K2300/00
Inventor 石小和
Owner 石小和
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