Preparation method and application of polypyrrole nanoparticles with controllable particle diameters

Abstract

The invention discloses a preparation method and application of polypyrrole nanoparticles with controllable particle diameters. The preparation method comprises the following steps of S1, preparing astabilizing agent solution, enabling the stabilizing agent solution to reflow, and performing natural cooling to room temperature; S2, dropwise adding an oxidizer to the stabilizing agent solution inS1, and performing uniform stirring to obtain a mixed solution; and S3, dropwise adding a polypyrrole monomer to the mixed solution obtained in S2, continuing to performing stirring for a reaction, and performing dialysis to obtain granular polypyrrole nanoparticles. The proportion of the stabilizing agent in a reaction system is adjusted and controlled, so that the dimension and the size of the polypyrrole nanoparticles can be adjusted and controlled, and the polypyrrole nanoparticles with controllable particle diameters can be obtained. The invention provides a synthesis method which is simple, feasible and green and can be used for massive preparation of the polypyrrole nanoparticles. According to the method, the size of the polypyrrole nanoparticles can be precisely adjusted and controlled, the micro polypyrrole nanoparticles can be prepared, the method can be applied to treatment of tumors by photothermal therapy, can discharge outside bodies from the kidney, and has high use value and clinical development potential.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, more specifically, to a preparation method and application of polypyrrole nanoparticles with controllable particle size. Background technique [0002] Polypyrrole (PPy) is a safe and non-toxic light-to-heat conversion material and a common conductive polymer with good photostability, chemical stability and biocompatibility, and has been widely used in organic Electronic products, battery energy, bioclinical and other fields. [Small 2010,6,679] Polypyrrole nanoparticles have strong near-infrared absorption. Armes et al. prepared polypyrrole nanoparticles as contrast agents for optical coherence tomography (OCT), which can significantly improve OCT imaging sensitivity. [Adv.Mater.2011,23,5792] In addition, PPy-based nanomaterials are also widely used in biosensors, drug delivery, and nerve regeneration. [Small 2010, 6, 421; Biomaterials 2010, 31, 1342]. [0003] The electrochemical ...

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Problems solved by technology

However, the size of nanoparticles prepared by this method is not uniform, and the size of polypyrrole nanoparticles cannot be precisely controlled, which has certain limitations [Colloids and Surfaces A, 2015, 483, 224-231]

At the same time, the polypyrrole nanoparticles prepared in the existing methods are generally larger than 100nm, and it is impossible to prepare ultra-small polypyrrole nanoparticles, and it is impossible to realize the excretion of polypyrrole nanoparticles from the kidneys, thereby achieving renal clearance.

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