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Medicine for treating allergic rhinitis and preparation method thereof

A technology for allergic rhinitis and drugs, applied in the field of pharmaceutical composition preparation, can solve the problems of physical instability, no consideration of adverse reactions, no consideration of adverse reactions and the like

Active Publication Date: 2020-10-30
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, the research on glucocorticoid drugs is relatively extensive. For example, Chinese patent document CN101273970A discloses a microemulsion for the nasal cavity of glucocorticoid anti-inflammatory drugs, which consists of an oil phase, an aqueous phase, an emulsifier and an emulsifying agent. It is a transparent or translucent, low-viscosity, isotropic uniform oil-water mixing system formed spontaneously in an appropriate proportion of the agent. It is also a kinetically and thermodynamically stable system. The purpose of its research is to overcome the physical instability of the water-suspension nasal spray problems, making the liquid medicine system more uniform and the dosage more accurate, but it does not consider the adverse reactions after use
In addition, the Chinese patent document CN108283621A discloses a nasal nano-preparation mometasone furoate liquid crystal gel nanoparticles, which has high drug encapsulation rate, sustained release time and improved absorption rate, without considering the effect of the added excipients on patients after use adverse reactions

Method used

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  • Medicine for treating allergic rhinitis and preparation method thereof
  • Medicine for treating allergic rhinitis and preparation method thereof
  • Medicine for treating allergic rhinitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The medicine for treating allergic rhinitis described in the present invention, the specific preparation steps are as follows:

[0025] 1) Use a pulverizer to pulverize mometasone furoate so that 90% of its particle size is less than 5 μm, and set aside;

[0026] 2) Dissolve 1.5g of a mixture of carboxypropylcellulose, hydroxyethylmethylcellulose and microcrystalline cellulose (1:1:4) with an appropriate amount of water for injection, stir and mix evenly, and pass through a 0.22μm sterile filter sterilization;

[0027] 3) Mix 0.05 g of mometasone furoate micropowder in step 1) with 2.0 g of sesame oil, add 0.6 g of glycerin, 2.5 g of Tween 80 and lecithin 1:2 mixture, 0.3 g of sodium chloride and mix homogeneously, Bacteria for 10 minutes to get the initial mixture;

[0028] 4 After homogeneously mixing the primary mixture obtained in step 3) with the solution in step 2), add 0.08g of peppermint oil, adjust to a suitable pH value of 6.0 with sodium citrate buffer, add...

Embodiment 2

[0030] The medicine for treating allergic rhinitis described in the present invention, the specific preparation steps are as follows:

[0031] 1) Use a pulverizer to pulverize mometasone furoate so that 90% of its particle size is less than 5 μm, and set aside;

[0032] 2) Dissolve 1.0 g of a mixture of carboxypropyl cellulose, hydroxyethyl methyl cellulose and microcrystalline cellulose (1:1:4) with an appropriate amount of water for injection, stir and mix evenly, and pass through a 0.22 μm sterile filter sterilization;

[0033] 3) Mix 0.04 g of mometasone furoate micropowder in step 1) with 1.5 g of sesame oil, add 0.5 g of glycerin, 2.2 g of Tween 80 and lecithin 1:2 mixture, 0.2 g of sodium chloride and mix homogeneously. Bacteria for 10 minutes to get the initial mixture;

[0034] 4 After homogeneously mixing the primary mixture obtained in step 3) with the solution in step 2), add 0.06 g of peppermint oil, adjust to a suitable pH value of 6.0 with sodium citrate buffe...

Embodiment 3

[0036]The medicine for treating allergic rhinitis described in the present invention, the specific preparation steps are as follows:

[0037] 1) Use a pulverizer to pulverize mometasone furoate so that 90% of its particle size is less than 5 μm, and set aside;

[0038] 2) Dissolve 1.5g of a mixture of carboxypropylcellulose, hydroxyethylmethylcellulose and microcrystalline cellulose (1:1:4) with an appropriate amount of water for injection, stir and mix evenly, and pass through a 0.22μm sterile filter sterilization;

[0039] 3) Mix 0.08 g of mometasone furoate micropowder in step 1) with 2.0 g of sesame oil, add 0.8 g of glycerin, 2.8 g of a mixture of Tween 80 and lecithin 1:2, and 0.4 g of sodium chloride, mix homogeneously, and extinguish Bacteria for 10 minutes to get the initial mixture;

[0040] 4 After homogeneously mixing the primary mixture obtained in step 3) with the solution in step 2), add 0.08g of peppermint oil, adjust to a suitable pH value of 6.0 with sodium...

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Abstract

The invention discloses a medicine for treating allergic rhinitis. The medicine comprises 0.04%-0.08% of mometasone furoate, 0.5%-0.8% of glycerol; 1.5%-2.0% of sesame oil; 0.1%-0.5% of sodium chloride, 0.5%-1.5% of a mixture of carboxypropyl cellulose, hydroxyethyl methyl cellulose and microcrystalline cellulose, 2%-3% of a mixture of Tween 80 and lecithin, 0.05%-0.1% of peppermint oil, a properamount of a sodium citrate buffer solution and the balance of water for injection. Experiments show that the medicine disclosed by the invention can be used for effectively treating allergic rhinitisand effectively reducing the occurrence rate of adverse reactions.

Description

technical field [0001] The invention belongs to the field of pharmaceutical composition preparations, and in particular relates to a pharmaceutical composition for treating allergic rhinitis and a preparation method thereof. Background technique [0002] Allergic rhinitis (allergic rhinitis, AR), also known as allergic rhinitis, is an allergic disease of the nasal mucosa. It is characterized by increased nasal mucosal reactivity. Itching, some with hyposmia, nearly 40% of allergic rhinitis patients can be combined with bronchial asthma, and can also be accompanied by pulmonary symptoms such as wheezing, coughing, shortness of breath and chest tightness, which directly affect the quality of life, sleep quality and mood of patients And work efficiency, etc., bring a heavy mental and psychological burden to patients, affecting the normal life of patients. At present, patients with allergic rhinitis account for 20%-30% of the total population in the world. In recent years, the ...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/58A61K47/38A61K47/44A61P11/02A61P37/08
CPCA61K9/0043A61K9/107A61K31/58A61K47/38A61K47/44A61P11/02A61P37/08
Inventor 李岩王殿一张竞飞汪静怡高雪娇谢良震
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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