Pharmaceutical composition for treating duodenal ulcer

Abstract

The invention discloses a pharmaceutical composition for treating duodenal ulcer. The pharmaceutical composition is prepared from 0.1-0.3 part of a compound shown in a formula I, 0.01-0.05 part of magnolol, 0.01-0.02 part of gallic acid and 0.05-0.1 part of methyl rosmarinate, and the pharmaceutical composition is prepared for external use. Experiments show that the pharmaceutical composition with the compound shown in the formula I, magnolol, gallic acid, methyl rosmarinate and flavanone glycoside as main components interacts with one another, can repair damaged intestinal wall tissue of rats and inhibit gastric acid secretion, and has a treatment effect on duodenal ulcer.

Description

technical field [0001] The invention belongs to the field of pharmaceutical composition preparations, in particular to a pharmaceutical composition for treating duodenal ulcer. Background technique [0002] Duodenal ulcer is one of the most common clinical diseases of the digestive system and is a common type of peptic ulcer. The cause of the disease may be related to Helicobacter pylori infection, it may also be related to the excessive secretion of gastric acid in patients, and it may also be related to the use of non-steroidal anti-inflammatory drugs, genetic factors, stress, irregular life and diet, work and external pressure , smoking, drinking and psychological factors are closely related. It occurs mainly in winter and spring when the climate changes greatly, and the incidence rate of men is significantly higher than that of women. [0003] Duodenal ulcers mostly occur in the duodenal bulb. Rhythmic and periodic pain in the upper abdomen or under the xiphoid process...

AI Technical Summary

Problems solved by technology

Due to the reasonable application of a large number of new acid-suppressing drugs, antacid drugs, mucosal protective agents and antibiotics, most patients with duodenal ulcer can be healed in a short period of time, but the disease cannot be cured fundamentally. The survey shows that the recurrence rate is high, and its high recurrence rate and a small number of refractory duodenal ulcers are still a major clinical problem to be solved urgently

Based on the above-mentioned observations on the clinical application of commonly used western medicines, more and more scholars believe that for the treatment of duodenal ulcer, the current types of medicines are limited, and although the effects are fast, the high recurrence rate makes the patients feel bad about the medicine. At the same time, the above-mentioned drugs may have certain adverse stimuli. Therefore, it is necessary to further study drugs that can clearly treat duodenal ulcer with small adverse reactions and low recurrence rates.

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