Misfolded tdp-43 binding molecules

A TDP-43, binding molecule technology, applied in the fields of drug combination, analytical materials, biomaterial analysis, etc., can solve problems such as complex diagnosis

Pending Publication Date: 2020-11-03
AC IMMUNE SA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Diagnosis of these syndromes is complex and conclusive conclusions can only be drawn by immunohistochemistry-based post-mortem tissue analysis to detect aggregated proteins and characterize affected brain regions

Method used

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  • Misfolded tdp-43 binding molecules
  • Misfolded tdp-43 binding molecules
  • Misfolded tdp-43 binding molecules

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Embodiment Construction

[0250] X. Definition

[0251] An "antigen binding molecule" as used herein is any molecule that can specifically or selectively bind to an antigen. A binding molecule may comprise or be an antibody or fragment thereof. Anti-misfolded TDP-43 binding molecules are molecules that bind misfolded TDP-43 protein at specific recognition sites (epitopes), such as anti-TDP-43 antibodies or fragments thereof. That is, the antigen-binding molecule of the present invention binds to an epitope in the amino acid sequence of SEQ ID NO: 1, preferably at amino acid positions 215 to 222 thereof. Other misfolding-resistant TDP-43 binding molecules can also include multivalent molecules, multispecific molecules (for example, diabodies (diabodies)), fusion molecules, aptamers, affimers (avimers) or other naturally occurring or recombinantly produced molecules. Exemplary antigen-binding molecules useful in the invention include antibody-like molecules. Antibody-like molecules are molecules that...

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Abstract

The present invention is in the field of transactive response DNA binding protein with a molecular weight of 43 kDa (TARDB or also TDP-43). The invention relates to TDP-43 specific binding molecules,in particular to anti-TDP-43 antibodies or an antigen-binding fragment or a derivative thereof and uses thereof. The present invention provides means and methods to diagnose, prevent, alleviate and / ortreat a disorder and / or abnormality associated with misfolded TDP-43 including but not limited to frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD, sporadicand familial), and / or Parkinson's disease (PD). The present invention provides modified conformation-specific antigenic peptides and peptide fragments derived from the TDP-43 protein and the antibodies obtainable by said peptides or fragments for use in the diagnosis, prevention, alleviation and / or treatment of TDP-43-related disorders and / or abnormalities.

Description

technical field [0001] The present invention is in the field of transactivation responsive DNA binding protein (TARDB or also known as TDP-43) having a molecular weight of 43 kDa. The present invention relates to TDP-43-specific binding molecules, especially anti-TDP-43 antibodies or antigen-binding fragments or derivatives thereof and uses thereof. The present invention provides means and methods for diagnosing, preventing, alleviating and / or treating disorders and / or abnormalities associated with misfolded TDP-43, including but not limited to frontotemporal dementia (FTD) , amyotrophic lateral sclerosis (ALS), Alzheimer's disease (Alzheimer's disease, AD, sporadic and familial) and / or Parkinson's disease (Parkinson's disease, PD). The present invention provides modified conformation-specific antigenic peptides and peptide fragments from TDP-43 protein and antibodies obtainable from said peptides or fragments for use in diagnosis, prevention, alleviation and / or treatment of ...

Claims

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Application Information

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IPC IPC(8): C07K16/18A61K39/395
CPCA61K39/395C07K16/18C07K2317/92G01N33/6896A61P25/28A61K2039/505A61K47/6843A61K47/6803A61K45/06C07K2317/34G01N2800/28
Inventor 塔玛拉·谢雷德尼纳奥斯卡·阿道夫松
Owner AC IMMUNE SA
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