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Application of jasminum grandiflorum and jasminum grandiflorum extract in preparation of medicine for treating hyperlipemia, metabolic syndrome or non-alcoholic fatty liver disease

A metabolic syndrome, non-alcoholic technology, applied in metabolic diseases, drug combinations, pharmaceutical formulas, etc., can solve problems such as unclearness and the influence of frangipani activity, achieve obvious effects, improve insulin sensitivity, and reduce fat content Effect

Active Publication Date: 2020-11-13
WUYI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of frangipani on lipid-lowering activity is unclear

Method used

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  • Application of jasminum grandiflorum and jasminum grandiflorum extract in preparation of medicine for treating hyperlipemia, metabolic syndrome or non-alcoholic fatty liver disease
  • Application of jasminum grandiflorum and jasminum grandiflorum extract in preparation of medicine for treating hyperlipemia, metabolic syndrome or non-alcoholic fatty liver disease
  • Application of jasminum grandiflorum and jasminum grandiflorum extract in preparation of medicine for treating hyperlipemia, metabolic syndrome or non-alcoholic fatty liver disease

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Embodiment Construction

[0025] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific examples.

[0026] 1. Experimental method

[0027] (1) Preparation of frangipani flower extract

[0028] Preparation of frangipani ethanol extract: Weigh an appropriate amount of dried frangipani, add ethanol with a volume fraction of 95% after crushing, and extract in a water bath at 80°C for 2 hours each time, filter and collect the extract after each extraction, and extract together 3 times, the combined extracts were concentrated with a rotary evaporator until there was no alcohol smell, and the ethanol extract was obtained.

[0029] Preparation of frangipani ethyl acetate extract: Dissolve the above ethanol extract into a suspension with distilled water, then add an appropriate amount of ethyl acetate solvent for extraction, leave to stand for layering, collect the ethyl acetate l...

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Abstract

The invention discloses application of jasminum grandiflorum and jasminum grandiflorum extract in preparation of medicine for treating hyperlipidaemia, metabolic syndrome or non-alcoholic fatty liverdisease, and belongs to the field of medicine. The jasminum grandiflorum and the jasminum grandiflorum extract have the advantages that the obesity caused by high-fat and high-cholesterol food can beobviously reduced; the related glucose tolerance damage is reduced; fat content is greatly reduced, levels of triglyceride and cholesterol in serum and liver of a mouse fed with high fat and high cholesterol can be remarkably reduced, phosphorylation of Akt in an insulin signal channel can be activated, and accordingly insulin sensitivity is improved. The invention develops the medicinal application of jasminum grandiflorum and the extract thereof, and provides a new possibility for treating hyperlipidaemia, metabolic syndrome or non-alcoholic fatty liver disease.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of Frangipani frangipani or its extract in the preparation of medicines for treating hyperlipidemia, metabolic syndrome or nonalcoholic fatty liver disease. Background technique [0002] Metabolic syndrome is a cluster of pathological conditions including type 2 diabetes, central obesity, dyslipidemia and hypertension [1] . Central obesity and insulin resistance (impaired ability of target tissues to respond to insulin) underlie the pathogenesis of metabolic syndrome [2] . One of the important dietary factors contributing to central obesity and insulin resistance is a high-fat diet because of its energy content and fatty acids that can have varying degrees of direct effect on insulin sensitivity [1,2] . Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, closely related to obesity and other metabolic syndromes [3,4] . [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/63A61P3/06A61P3/00A61P1/16
CPCA61K36/63A61P3/06A61P3/00A61P1/16A61K2236/333A61K2236/35A61K2236/39
Inventor 李冬利周秀叶冀明吴日辉黄毅祺谢寅正周致言李慧芳张焜
Owner WUYI UNIV
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