Osteosarcoma prognosis marker and prognosis evaluation model

A technology for osteosarcoma and prognosis, which is applied in biochemical equipment and methods, microbial determination/examination, instruments, etc., to achieve the effects of high prediction accuracy, good prognosis, and improved 5-year survival rate
CN112063720AActive Publication Date: 2020-12-11SHANGHAI FIRST PEOPLES HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI FIRST PEOPLES HOSPITAL
Publication Date
2020-12-11

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Abstract

The invention relates to an osteosarcoma prognosis marker and prognosis evaluation model. According to the osteosarcoma prognosis marker and prognosis evaluation model, overall survival time data of osteosarcoma patients in two independent databases of TARGET and GSE21257 are integrated, glycolysis-related genes P4HA1, ABCB6 and STC2 are screened and verified as osteosarcoma prognosis markers, anda prognostic risk assessment model is constructed based on the P4HA1, ABCB6 and STC2, and by a training set and a verification set, it is verified that the model has relatively high accuracy, and further analysis finds that the risk score of the model is also significantly related to metastasis and tumor immune microenvironment. The osteosarcoma prognosis marker and prognosis evaluation model areconducive to better predicting prognosis conditions of the osteosarcoma patients, and can bring great help for guiding clinical treatment of the osteosarcomas.
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Description

technical field

[0001] The present invention relates to the prognosis assessment of diseases, in particular, to the osteosarcoma prognosis marker and prognosis assessment model. Background technique

[0002] Osteosarcoma is a malignant tumor primary in bone tissue that is common in children and adolescents. It is prone to recurrence and metastasis. Lung metastasis is the main cause of death in osteosarcoma patients. At present, the preferred treatment option for patients with osteosarcoma is neoadjuvant chemotherapy combined with surgery. This treatment option has greatly improved the 5-year survival rate of patients, but once the patient develops lung metastasis, the 5-year survival rate is still lower than 20%. Therefore, it is of great scientific and social significance to explore the mechanism of occurrence and metastasis of osteosarcoma at the molecular level and lay the foundation for the early diagnosis and prognosis evaluation of osteosarcoma. Finding effective prog...

Claims

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