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Tomoxetine hydrochloride oral liquid and preparation method thereof

A technology of atomoxetine hydrochloride and oral solution is applied in the field of medicine to achieve the effects of improving taste, consistent quality and reducing bitterness

Pending Publication Date: 2020-12-15
JIANGSU ALPHA PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is to improve the mouthfeel of atomoxetine hydrochloride oral liquid when taken and the problems of bitterness and numbness after taking it, and improve the patient's medication compliance without affecting the stability and other qualities of the drug.

Method used

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  • Tomoxetine hydrochloride oral liquid and preparation method thereof
  • Tomoxetine hydrochloride oral liquid and preparation method thereof
  • Tomoxetine hydrochloride oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Prescription composition:

[0029]

[0030] Preparation process: (1) Add methylcellulose into purified water, heat to 80-90°C, stir and disperse evenly, then add atomoxetine hydrochloride, stir well and dissolve evenly. Cool to 40-50°C; (2) Add preservatives, pH regulators, and flavoring agents to the above solution, and stir to dissolve. Cool to room temperature. (3) Filter and add purified water to the full amount; (4) Divide, 100mL / bottle.

Embodiment 2

[0032] Prescription composition:

[0033]

[0034]

[0035] Preparation process: (1) Add methylcellulose into purified water, heat to 80-90°C, stir and disperse evenly, then add atomoxetine hydrochloride, stir well and dissolve evenly. Cool to 40-50°C; (2) Add preservatives, pH regulators, and flavoring agents to the above solution, and stir to dissolve. Cool to room temperature. (3) Filter and add purified water to the full amount; (4) Divide, 100mL / bottle.

Embodiment 3

[0037] Prescription composition:

[0038]

[0039] Preparation process: (1) Add methylcellulose into purified water, heat to 80-90°C, stir and disperse evenly, then add atomoxetine hydrochloride, stir well and dissolve evenly. Cool to 40-50°C; (2) Add preservatives, pH regulators, and flavoring agents to the above solution, and stir to dissolve. Cool to room temperature. (3) Filter and add purified water to the full amount; (4) Divide, 100mL / bottle.

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PUM

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Abstract

The invention belongs to the technical field of medicines, particularly relates to the field of pharmacy, and more particularly relates to a tomoxetine hydrochloride oral liquid and a preparation method thereof. The tomoxetine hydrochloride oral liquid is mainly prepared from tomoxetine hydrochloride, a preservative, a pH regulator, a sweetening agent and a taste improver, wherein the taste improver is prepared from a thickening agent, mint essence and sweet orange essence. The taste improver prepared from the thickening agent, the mint essence and the sweet orange essence can significantly improve the taste of the tomoxetine hydrochloride oral liquid in the taking process, and significantly reduces the bitter taste during taking and the bitter taste of the oral cavity after taking. Meanwhile, a test verifies that the drug effect and the drug stability of an active drug are not affected by adding of the taste improver, and the quality of the tomoxetine hydrochloride oral liquid can beconsistent with that of an original drug.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to the field of pharmacy, and more specifically relates to atomoxetine hydrochloride oral liquid and a preparation method thereof. Background technique [0002] Attention deficit hyperactivity disorder (ADHD) syndrome, the names used in the past include mild brain dysfunction, attention deficit hyperactivity disorder, hyperactivity and so on. His core symptom is attention deficit, which is divided into attention deficit with hyperactivity disorder and attention deficit without hyperactivity disorder. It is one of the most common psychobehavioral disorders in childhood behavior, emotion and cognition. [0003] The chemical name of atomoxetine hydrochloride is: (R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropylamine hydrochloride, and its structural formula is: [0004] [0005] Atomoxetine hydrochloride was developed by U.S. Eli Lilly and Company in the 1980s and was listed in the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/138A61K47/36A61K47/38A61K47/40A61K47/46A61P25/14
CPCA61K31/138A61K9/0095A61K47/46A61K47/38A61K47/36A61K47/40A61P25/14
Inventor 陈本顺石利平叶金星李大伟张维冰徐春涛程瑞华钱若灿郭炳华朱小亮刘春河何义
Owner JIANGSU ALPHA PHARM CO LTD