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Throat spray and preparation method thereof

A composition and technology of sodium carboxymethyl cellulose, applied in the fields of health care and medical treatment, can solve the problems of large side effects, expensive medicines, difficult for patients to accept, etc., and achieve the effect of reducing evaporation and being suitable for long-term use.

Inactive Publication Date: 2020-12-22
SHAANXI BIO REGENERATIVE MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, medicines are expensive and have relatively large side effects, and for patients with dry mouth and chronic diseases, such as diabetes patients, medicines cannot be used for a long time
At the same time, there are a variety of gargles or saliva substitutes for relieving xerostomia on the market. For example, those with flaxseed gum as the main ingredient have special tastes, which are not easily accepted by patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] This embodiment provides a composition, according to mass percentage, including: polysorbate 80 2.0%, glycerin 15.0%, sodium chloride 0.5%, sodium edetate 0.3%, citric acid 0.3%, sodium citrate 0.2% , sodium carboxymethyl cellulose 0.2%, potassium sorbate 0.3% and purified water 81.2%.

[0021] This embodiment further provides the application of the composition in the preparation of medicament for alleviating oropharyngeal dryness.

[0022] This embodiment further provides a throat spray, which comprises the above composition.

[0023] This embodiment further provides the preparation method of the above-mentioned throat spray:

[0024] 1) Heat purified water, glycerin, and sodium carboxymethyl cellulose to 70-80°C, stir at 250 rpm to completely dissolve sodium carboxymethyl cellulose, and cool to about 40°C;

[0025] 2) Add polysorbate 80, sodium chloride, sodium edetate, citric acid, sodium citrate, and potassium sorbate to the mixed liquid treated in step 1), and th...

Embodiment 2

[0027] This embodiment provides a composition, according to mass percentage, including: polysorbate 80 3.0%, glycerin 20.0%, sodium chloride 1.0%, sodium edetate 0.5%, citric acid 0.2%, sodium citrate 0.2% , sodium carboxymethyl cellulose 0.1%, potassium sorbate 0.3% and purified water 74.7%.

[0028] This embodiment further provides the application of the above-mentioned composition in the preparation of a medicine for alleviating dryness of the oropharynx.

[0029] This embodiment further provides a throat spray, which comprises the above composition.

[0030] This embodiment further provides the preparation method of the above-mentioned throat spray:

[0031] 1) Heat purified water, glycerin, and sodium carboxymethyl cellulose to 70-80°C, stir at 250 rpm to completely dissolve sodium carboxymethyl cellulose, and cool to about 40°C;

[0032] 2) Add polysorbate 80, sodium chloride, sodium edetate, citric acid, sodium citrate, and potassium sorbate to the mixed liquid treate...

Embodiment 3

[0034] This embodiment provides a composition, according to mass percentage, including: polysorbate 80 5.0%, glycerin 18.0%, sodium chloride 1.0%, edetate sodium 0.5%, citric acid 0.3%, sodium citrate 0.3% , sodium carboxymethyl cellulose 0.08%, potassium sorbate 0.3% and purified water 74.52%

[0035] This embodiment further provides the application of the above-mentioned composition in the preparation of a medicine for alleviating dryness of the oropharynx.

[0036] This embodiment further provides a throat spray, which comprises the above composition.

[0037] This embodiment further provides the preparation method of the above-mentioned throat spray:

[0038] 1) Heat purified water, glycerin, and sodium carboxymethyl cellulose to 70-80°C, stir at 250 rpm to completely dissolve sodium carboxymethyl cellulose, and cool to about 40°C;

[0039] 2) Add polysorbate 80, sodium chloride, sodium edetate, citric acid, sodium citrate, and potassium sorbate to the mixed liquid treat...

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PUM

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Abstract

The invention relates to a throat spray capable of alleviating xerostomia and pharyngoxerosis, and a preparation method thereof, and belongs to the medical field, the health care technology field andthe technical field of medical apparatus. The throat spray consists of the following ingredients in parts by weight: 2.0-8.0% of polysorbate 80, 10-25% of glycerin, 0.3-1.0% of sodium chloride, 0.1-0.8% of edetate sodium, 0.05-0.3% of sodium carboxymethylcellulose, 0.1-0.5% of citric acid, 0.1-0.5% of sodium citrate, 0.2-0.5% of potassium sorbate and the balance of purified water. The throat sprayobtained by processing through technologies, including liquid blending, filling and the like, has good biocompatibility and moisturizing properties. The product disclosed by the invention does not contain antibiotics, hormones and the like, is nontoxic to the human body, does not irritate the mucosa, is not sensitized, is harmless, is high in safety, is produced on a large scale, has a simple technology and does not pollute the environment in a production process.

Description

technical field [0001] The invention relates to the technical field of medicine and health care and the technical field of medical equipment, in particular to a throat spray and a preparation method thereof. Background technique [0002] Oropharyngeal dryness is the decrease in secretion or increase in consumption of saliva in the oral cavity due to various reasons, and a negative balance of saliva secretion and consumption occurs in the oral cavity, resulting in dry oropharynx. With the improvement of people's quality of life and the enhancement of self-care awareness, more and more patients seek medical treatment for oral and pharyngeal xerostomia, accounting for about 10% of the population; and among the elderly over 65 years old, more than 30% of patients with xerostomia %. [0003] There are various reasons for oropharyngeal dryness. At present, during the clinical perioperative period, such as pancreas surgery patients, patients are fasting and drinking water. Because...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K47/26A61K47/10A61K47/02A61K47/18A61K47/12A61K47/38A61P1/02A61P11/04
CPCA61K9/006A61K47/26A61K47/10A61K47/02A61K47/183A61K47/12A61K47/38A61P1/02A61P11/04
Inventor 周斌冯会平
Owner SHAANXI BIO REGENERATIVE MEDICINE CO LTD
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