A kind of trifluoromethylated aniline compound and application thereof

A technology for trifluoromethylated aniline and compounds, which is applied in the field of trifluoromethylated aniline compounds, can solve the problems of uncertain action, low yield, increased research cost and difficulty, and achieve mild reaction conditions, high reaction efficiency, The direct effect of the trifluoromethylation modification method
CN112125838BActive Publication Date: 2021-07-27ZHEJIANG UNIV OF TECH
2 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Publication Date
2021-07-27

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The present invention provides a trifluoromethylated aniline compound represented by formula (I), its preparation method and application. In the present invention, compounds such as aminoglutethimide are modified by trifluoromethylation, and the operation process is simple, and the sources of raw materials are commercially available; and after modification, the anti-tumor activity, especially the anti-cervical cancer activity, is significantly improved, especially the compound ( The antitumor activity of Ia) is more than double that of aminoglutethimide. Compared with the previous aniline drug modification method, the trifluoromethylation modification method adopted in the present invention is more direct, efficient and fast.
Need to check novelty before this filing date? Find Prior Art

Description

[0001] (1) Technical field

[0002] The invention belongs to the technical field of organic chemistry, and in particular relates to a trifluoromethylated aniline compound and an application thereof.

[0003] (2) Background technology

[0004] Tumor is a new organism formed by the body under the action of various tumorigenic factors, and the cells of local tissues lose their normal regulation of their growth at the gene level, resulting in abnormal proliferation and differentiation. Tumor has the characteristics of fast growth, easy metastasis, difficult to cure, and high lethality. It is a major disease that seriously threatens the safety of human life. There are many anti-tumor drugs, and aminoglutethimide is one of them. Aminoglutethimide can inhibit the production of estrogen by blocking aromatase, thereby reducing the promotion effect of estrogen on breast cancer and inhibiting tumor growth. Bacteria are both useful and harmful to the environment, humans and animals. Som...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More