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Application of 1, 2, 4-trimethoxybenzene to prevention and treatment of post-traumatic stress disorder

A technology of post-traumatic stress and trimethoxybenzene, which is used in the treatment of post-traumatic stress disorder. The application field of 1,2,4-trimethoxybenzene in the prevention and treatment of post-traumatic stress disorder can solve the problem of Problems such as the decline in combat ability of sick officers and soldiers

Active Publication Date: 2021-01-15
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The technology described in this patented product improves its effectiveness compared with existing products that are currently available on market today.

Problems solved by technology

This patented technical problem addressed in this patent relates to finding ways for individuals experiencing post-Traumatic Stress Disorders (PTS), such as those caused by extreme weather conditions like snowstorms, explosions, fires, etc., without causing physical harm during their return journey back home.

Method used

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  • Application of 1, 2, 4-trimethoxybenzene to prevention and treatment of post-traumatic stress disorder
  • Application of 1, 2, 4-trimethoxybenzene to prevention and treatment of post-traumatic stress disorder
  • Application of 1, 2, 4-trimethoxybenzene to prevention and treatment of post-traumatic stress disorder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1,2,4-Trimethoxybenzene (purchased from Sigma-Aldrich) accelerated fear memory extinction.

[0025] Experimental steps:

[0026] ① 40 male mice weighing about 20g (strain C57, aged 8 weeks, purchased from Victoria Lihua) were randomly divided into 4 groups (no drug group, simple drug group, PTSD model group, PTSD model drug group) , 10 in each group. The PTSD model group and the model administration group were modeled according to the following PTSD modeling method.

[0027] ②PTSD modeling: put the mice in a light-tight shock box, and the lower part of the box is a stainless steel fence that can pass through the current, so that the mice are in a state where they cannot escape the continuous current stimulation of the feet, and the stimulation current intensity is 0.8mA; the experiment is divided into Two phases: free activity time (5min) and stimulation time (5min, 10s stimulation, 10s interval). The electric shock box was wiped with 75% alcohol between each mouse d...

Embodiment 2

[0032] ① 1,2,4-Trimethoxybenzene (purchased from Sigma-Aldrich) improves PTSD scene fear symptoms.

[0033] ②Experimental steps: grouping and PTSD modeling according to Example 1, administration for 3 consecutive days after PTSD modeling, and then test the fear memory of the mice to the environment in which the modeling occurred on the 14th day after PTSD modeling, that is, scene fear . The test method is to put the mouse back into the electric shock box, and record the immobility time of the mouse within 5 minutes.

[0034] ③ if figure 2 As shown, the results showed that: first, compared with the control group, the immobility time of the model group increased significantly; after administration of 1,2,4-trimethoxybenzene, the increase of immobility time caused by PTSD modeling could be reversed, and second There were significant differences between them, indicating that 1,2,4-trimethoxybenzene can improve the scene fear symptoms of PTSD.

Embodiment 3

[0036] ①1,2,4-Trimethoxybenzene (purchased from Sigma-Aldrich) improves PTSD depressive symptoms.

[0037] ②Experimental procedure: grouping and PTSD modeling according to Example 1, administration for 3 consecutive days after PTSD modeling, and then test the depressive symptoms of mice by tail suspension test on the 14th day after PTSD modeling. The tail suspension test method is as follows: the mouse is suspended at a height of 80 cm from the ground by the end of its tail, kept in the air, and then recorded with a video recorder. Data analysis: The non-struggling time of mice within 5 minutes after tail suspension was counted.

[0038] ③ if image 3 As shown, the results showed that: firstly, compared with the control group, the non-struggling time of the model group was significantly increased; after administration of 1,2,4-trimethoxybenzene, the increase of non-struggling time caused by PTSD modeling could be reversed; There was a significant difference between them, ind...

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Abstract

The invention discloses a compound 1, 2, 4-trimethoxybenzene. The 1, 2, 4-trimethoxybenzene can be used for treating post-traumatic stress disorder, and the result shows that the 1, 2, 4-trimethoxybenzene can obviously improve the scene fear, depression and anxiety symptoms of the post-traumatic stress disorder.

Description

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Claims

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Application Information

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Owner ACADEMY OF MILITARY MEDICAL SCI
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