An injection-type magnesium-based carbon nanotube composite microsphere activated calcium phosphate bio-bone adhesive and its preparation method and application

A carbon nanotube composite and bone adhesive technology, which is applied in microcapsules, drug delivery, tissue regeneration, etc., can solve the problems of insufficient osteoinductive activity, long degradation time, and low mechanical strength, so as to ensure continuous proliferation and maintain The pH value is stable and the effect of solving the problem of low mechanical strength

Active Publication Date: 2022-05-17
郝定均
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Problems solved by technology

[0007] In order to overcome the above-mentioned shortcoming of the prior art, the object of the present invention is to provide a kind of injection-type magnesium-based carbon nanotube composite microsphere activated calcium phosphate bio-bone adhesive and its preparation method and application, to solve the problems in the above-mentioned prior art. The mentioned disadvantages of calcium phosphate cement (CPC) are low mechanical strength, long degradation time and insufficient osteoinductive activity

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  • An injection-type magnesium-based carbon nanotube composite microsphere activated calcium phosphate bio-bone adhesive and its preparation method and application
  • An injection-type magnesium-based carbon nanotube composite microsphere activated calcium phosphate bio-bone adhesive and its preparation method and application
  • An injection-type magnesium-based carbon nanotube composite microsphere activated calcium phosphate bio-bone adhesive and its preparation method and application

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preparation example Construction

[0047] The preparation method of the injection-type magnesium-based carbon nanotube composite microsphere activated calcium phosphate bio-bone adhesive disclosed by the present invention comprises the following steps:

[0048] 1) Preparation of magnesium-based metal particles

[0049] Add 20% potassium dihydrogen phosphate solution to 2 g of Mg-based alloy particles, soak and react at room temperature for 12 hours, take it out, rinse with deionized water for 10 seconds, and detect by X-ray diffraction (XRD), it shows that potassium magnesium phosphate (KMgPO4) Coated Mg-based metal particles.

[0050] 2) Preparation of magnesium-based polylactic acid-glycolic acid copolymer microspheres Mg-MWCNT-PLGA

[0051] Dissolve PLGA (LA / GA=50:50, Mw=30,000-50,000) in dichloromethane to prepare a solution of 3-12% (w / v), and add Mg base at a ratio of 0.1-10wt% Metal particles, while adding carboxylated multi-walled CNT in a ratio of 0.1-0.5wt%, adding it to a 100mL beaker, placing it i...

application example 1

[0059] Each component of preparation above-mentioned bone adhesive is passed through 60 Packaged after Co irradiation sterilization, the above-mentioned Mg-MWCNT-PLGA composite microspheres (Mg: 0.1-10wt%, CNT: 0.1-0.5wt%) and CPC solid powder were mixed uniformly at room temperature in the operating room environment (micro ball: 1-25wt%), add a curing agent containing citric acid or phosphate buffer, fully stir at room temperature for 1min (solid powder and curing agent ratio 10g: 6ml), mix evenly according to the above ratio and hydrate for 5min Finally, inject the special push rod through a 20mL syringe for standby, and the injection time of bone adhesive can be controlled within 10-20min.

[0060] After detailed preoperative examination and systematic evaluation, elderly OVCF patients need minimally invasive surgery including percutaneous kyphoplasty (PKP) / percutaneous vertebroplasty (PVP) to restore the height of the fractured vertebral body, Relieve the symptoms of low ...

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Abstract

The invention discloses an injection-type magnesium-based carbon nanotube composite microsphere activated calcium phosphate bio-bone adhesive and its preparation method and application, belonging to the field of orthopedic biodegradable biomaterials. Magnesium-based metal particles and multi-walled carbon nanotubes Combined magnesium-based polylactic acid-glycolic acid copolymer (Mg-MWCNT-PLGA) microspheres are used as the activation component, CPC solid powder is used as the substrate component, and citric acid or phosphate buffer is used as the curing agent. The bio-bone adhesive of the present invention has good osteoinductive activity and strong mechanical properties, and can solve the problems of low mechanical strength, long degradation time and osteoinductive defects of calcium phosphate cement (CPC) mentioned in the prior art. Due to the deficiency of activity, it has broad clinical application value.

Description

technical field [0001] The invention belongs to the field of orthopedic biodegradable biomaterials, and relates to an injectable magnesium-based carbon nanotube composite microsphere-activated calcium phosphate bio-bone adhesive with excellent osteogenic activity and a preparation method and application thereof. Background technique [0002] With the prolongation of life expectancy, the incidence of osteoporotic vertebral compression fractures (OVCF) is increasing day by day, and minimally invasive procedures such as percutaneous kyphoplasty (PKP) / percutaneous vertebroplasty (PVP) have become its main treatment. Calcium phosphate cement (CPC) has also been applied in the minimally invasive surgical treatment of OVCF. It has good biocompatibility in vivo, but due to its low mechanical strength, long degradation time in vivo, and lack of Osteogenic activity limits its wide application. [0003] Degradable magnesium (Mg)-based metal materials have good biological safety and s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04A61L27/08A61L27/12A61L27/18A61L27/50A61L27/54A61L27/58
CPCA61L27/18A61L27/047A61L27/08A61L27/12A61L27/54A61L27/50A61L27/58A61L2300/102A61L2300/412A61L2300/622A61L2400/06A61L2400/12A61L2430/02C08L67/04
Inventor 郝定均贾帅军朱雷田方张鹰王致远
Owner 郝定均
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