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Bcl-2 INHIBITORS

A pharmaceutical, independent technology applied in the field of Bcl-2 inhibitors

Active Publication Date: 2021-03-02
BEIGENE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its efficacy in these settings is limited by platelet death and the concomitant thrombocytopenia caused by Bcl-xL inhibition (Lancet Oncol. 2010, 11, 1149; J. Clin. Oncol. 2011, 29, 909; J. Clin. Oncol. 2012, 30, 488)

Method used

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Embodiment Construction

[0196] definition

[0197] The following terms have indicated meanings throughout the specification:

[0198] As used herein (including the appended claims), singular words such as "a," "an," and "the" include their corresponding plural referents unless the context clearly dictates otherwise.

[0199] The term "or" is used to mean and is used interchangeably with the term "and / or" unless the context clearly dictates otherwise.

[0200] The term "alkyl" refers to a hydrocarbon group selected from linear and branched saturated hydrocarbon groups, comprising 1 to 18 (such as 1 to 12, further such as 1 to 10, further such as 1 to 8, or 1 to 6, or 1 to 4) carbon atoms. Alkyl groups containing 1 to 6 carbon atoms (i.e. C 1-6 Examples of alkyl) include, but are not limited to, methyl, ethyl, 1-propyl or n-propyl ("n-Pr"), 2-propyl or isopropyl ("i-Pr"), 1-butyl or n-butyl ("n-Bu"), 2-methyl-1-propyl or isobutyl ("i-Bu"), 1-methylpropyl or sec-butyl ("s-Bu" ), 1,1-dimethylethyl ...

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Abstract

Disclosed herein is a compound of Formula (I) for inhibiting Bcl-2 and treating disease associated with undesirable bcl-2 activity (Bcl-2 related diseases), a method of using the compounds disclosed herein for treating dysregulated apoptotic diseases including cancers and treating autoimmune disease, and a pharmaceutical composition comprising the same.

Description

[0001] This application claims the benefit of International Patent Application No. PCT / CN 2018 / 085217, filed April 29, 2018, and International Patent Application No. PCT / CN 2018 / 107134, filed September 21, 2018, which are disclosed for all purposes The content is hereby incorporated by reference in its entirety. technical field [0002] Disclosed herein is a compound of formula (I) for inhibiting Bcl-2 and treating diseases associated with unwanted bcl-2 activity (Bcl-2-associated diseases). Method for disorders such as Alzheimer's disease and dysregulated apoptotic diseases including proliferative diseases such as cancer, autoimmune diseases and pro-thrombotic disorders, and a compound comprising said pharmaceutical composition. Background technique [0003] Programmed cell death, or apoptosis, occurs in multicellular organisms to dispose of damaged or unwanted cells and is critical for normal tissue homeostasis. (Br. J. Cancer 1972, 26, 239). However, defective apoptoti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D403/12A61K31/496A61P35/00
CPCC07D471/04A61P35/00C07D403/12C07D519/00C07D405/14C07D471/14C07D207/09A61K31/437A61K31/496
Inventor 郭运行薛海王志伟孙汉资
Owner BEIGENE