Pulsed electric field ablation parameter optimization system

A pulsed electric field and parameter technology, applied in the field of medical devices, can solve problems such as time-consuming and laborious, over-treatment, etc., and achieve the effects of reducing over-treatment, improving accuracy, and reducing experience requirements

Active Publication Date: 2021-03-12
REMEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

On the one hand, in the actual treatment process, it needs to be adjusted according to the individual characteristics of the patient, which requires medical technicians to conduct a large number of animal experiments and conduct clinical treatment under the guidance of experienced d

Method used

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  • Pulsed electric field ablation parameter optimization system
  • Pulsed electric field ablation parameter optimization system
  • Pulsed electric field ablation parameter optimization system

Examples

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Embodiment 1

[0100] This embodiment takes a specific application scenario as an example, and provides an implementation manner in which the database construction module constructs the historical patient database, so as to more clearly illustrate the technical solution proposed by the embodiment of the present invention, and is not a reference to the embodiment of the present invention limit.

[0101] The database construction module constructs the historical patient database, which may include:

[0102] 100. Obtain the simulation current ratio corresponding to the preselected conductivity ratio under the pre-pulse field strength and use the preselected ablation parameter combination, and construct a simulation database;

[0103] In an embodiment, the simulation database can use the COMSOL multiphysics simulation platform or other simulation tools to establish a numerical simulation model of pulsed electric field ablation. For example, the preselected ablation parameters and their preselec...

Embodiment 2

[0145] In this embodiment, the optimization of a single group of electrode needle ablation parameter combinations is exemplified to illustrate the main aspects of the embodiments of the present invention more clearly, and should not be construed as a limitation to the embodiments of the present invention. The needle scheme adopted by a single group of electrode needles is generally a filling needle arrangement scheme.

[0146] Determine the size and shape of the lesion based on medical imaging data such as MRI or ultrasound, assuming that the area of ​​the lesion is A L . Reasonable placement of needles in the lesion area. This embodiment mainly describes the layout of a single group of electrode needles. Therefore, two electrode needles are placed in the lesion area as an example to complete the ablation. Figure 5 It is a schematic diagram of a single group of electrode needles, and the distance between electrode needles can be determined from this figure. In this embodime...

Embodiment 3

[0171] In this embodiment, the parameter optimization of multiple groups of electrode needle ablation parameters is exemplified to illustrate the main aspects of the embodiment of the present invention more clearly, and should not be construed as a limitation to the embodiment of the present invention. For the situation where a single set of electrode needles cannot be used to complete the treatment, multiple sets of electrode needles need to be used for treatment. During the treatment process of multiple groups of electrode needles, the ablation area treated by each group of electrode needles needs to be determined first, and finally the ablation area treated by each group of electrode needles is superimposed to obtain the final ablation area.

[0172] Assume that a patient's lesions such as Figure 6 As shown, due to the small size of the lesion area, the filling needle placement scheme can be selected, and 4 electrode needles are evenly arranged in the lesion area for ablat...

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Abstract

The invention relates to a pulsed electric field ablation parameter optimization system, which comprises an estimation module used for estimating basic data of a current patient based on basic data ofa historical patient, wherein the basic data is used for representing electrical characteristics and muscle jitter characteristics of the tissue of the patient under the pre-pulse field intensity; and an optimization module that is used for selecting an optimal ablation parameter combination for the current patient from multiple groups of ablation parameter combinations by using an optimization strategy based on the basic data of the current patient. According to the pulsed electric field ablation parameter optimization system provided by the embodiment of the invention, based on the basic data of historical patients, an optimization strategy is used, and the individual biological conditions of the patients can be fully considered for different individual patients, so that a personalizedtreatment plan is given, the tumor ablation accuracy is improved and the experience requirements on medical personnel are reduced. Therefore, a medical staff can quickly form clinical treatment experience, and excessive treatment can be effectively reduced.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a pulse electric field ablation parameter optimization system. Background technique [0002] Cancer is a major disease that endangers human health. The growth process of the tumor has undergone multiple divisions and proliferation, and its daughter cells have obvious differences in tumor growth speed, invasion ability, drug sensitivity, etc., and different patients have different tumor shapes. Therefore, traditional treatment methods are used. Its curative effect is weak. At present, personalized precision treatment has become the development direction of modern medicine, but the heterogeneity of tumors seriously reduces the precision of tumor treatment. [0003] In order to improve the accuracy of tumor treatment, the current electric field ablation treatment planning method has made gratifying developments, but there are still some limitations. On the one...

Claims

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Application Information

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IPC IPC(8): G16H10/60G16H20/40G16H40/60G16H50/70A61B18/12
CPCG16H40/60G16H10/60G16H50/70G16H20/40A61B18/12A61B2018/00577A61B2018/00875
Inventor 罗中宝王海峰
Owner REMEDICINE CO LTD
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