Improved preparation method of ligusticum wallichii tea-regulating pharmaceutical composition

A Chuanxiong tea blending and composition technology, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of difficult control of dripping speed, low content of active ingredients, and small viscosity, and achieve improved Product quality, simple method, guarantee the effect of medicines

Pending Publication Date: 2021-03-16
贵州健兴药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problems in the application number CN200910307436.4: 1) Incomplete extraction by steam distillation, resulting in low active ingredient content; 2) The temperature of the feed liquid reaches 100°C, the viscosity is small, and the dropping speed is difficult to control, which affects the roundness of the dropping pills 3) The drop distance, drop speed, and condensing agent temperature are unsuitable, which affects the quality of the finished product

Method used

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  • Improved preparation method of ligusticum wallichii tea-regulating pharmaceutical composition
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  • Improved preparation method of ligusticum wallichii tea-regulating pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Preparation

[0040] 1) Take the selected Chinese Rhizoma Chuanxiong, Notopterygium, Asarum, Fangfeng, Peppermint, and Schizonepetae, add 8 times the amount of 60% dilute ethanol and soak for 2 hours; After 1 hour, collect the extract;

[0041] 2) Put the drug residue after extraction in step 1) and the selected Angelica dahurica and Radix Glycyrrhizae into the extraction tank, decoct twice, add 10 times the amount of 60% dilute ethanol for the first time, heat to boil, and keep a slight boil for 2 hour, filter at 120 mesh; add 10 times the amount of water for the second time, heat to boiling, keep boiling slightly for 2 hours, filter at 120 mesh, and collect the filtrate;

[0042] 3) combining the extract of step 1) and the filtrate of step 2), and concentrating under reduced pressure to 50°C, a thick paste with a relative density of 1.35;

[0043] 4) Weigh the matrix polyethylene glycol 6000 of 5 times the amount of the thick paste, heat it in an oil bath until it m...

Embodiment 2

[0046] Preparation

[0047]1) Take the selected Chinese Rhizoma Chuanxiong, Notopterygium, Asarum, Fangfeng, Peppermint, and Schizonepetae, add 8 times the amount of 60% dilute ethanol and soak for 2 hours; After 1 hour, collect the extract;

[0048] 2) Put the drug residue after extraction in step 1) and the selected Angelica dahurica and Radix Glycyrrhizae into the extraction tank, decoct twice, add 10 times the amount of 60% dilute ethanol for the first time, heat to boil, and keep a slight boil for 2 hour, filter at 120 mesh; add 10 times the amount of water for the second time, heat to boiling, keep boiling slightly for 2 hours, filter at 120 mesh, and collect the filtrate;

[0049] 3) combining the extract of step 1) and the filtrate of step 2), and concentrating under reduced pressure to 50°C, a thick paste with a relative density of 1.35;

[0050] 4) Weigh the matrix polysorbate 5 times the amount of the thick paste, heat it in an oil bath until it melts, add the thi...

Embodiment 3

[0053] Preparation

[0054] 1) Take the selected Chinese Rhizoma Chuanxiong, Notopterygium, Asarum, Fangfeng, Peppermint, and Schizonepetae, add 8 times the amount of 60% dilute ethanol and soak for 2 hours; After 1 hour, collect the extract;

[0055] 2) Put the drug residue after extraction in step 1) and the selected Angelica dahurica and Radix Glycyrrhizae into the extraction tank, decoct twice, add 10 times the amount of 60% dilute ethanol for the first time, heat to boil, and keep a slight boil for 2 hour, filter at 120 mesh; add 10 times the amount of water for the second time, heat to boiling, keep boiling slightly for 2 hours, filter at 120 mesh, and collect the filtrate;

[0056] 3) combining the extract of step 1) and the filtrate of step 2), and concentrating under reduced pressure to 50°C, a thick paste with a relative density of 1.35;

[0057] 4) Weigh the matrix poloxamer of 5 times the amount of the thick paste, heat it in an oil bath until it melts, add the t...

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Abstract

The invention relates to an improved preparation method of a ligusticum wallichii tea-regulating pharmaceutical composition. The preparation method comprises the following steps of: mixing an extracting solution obtained by carrying out reflux extraction on the raw medicinal materials including ligusticum wallichii, notopterygium root, asarum, divaricate saposhnikovia root, mint and schizonepeta with an extracting solution obtained by decocting the raw medicinal materials including radix angelicae and liquorice, carrying out vacuum concentration to obtain thick paste, and then adding a matrixin a certain proportion to prepare the ligusticum wallichii tea-regulating pharmaceutical composition. The preparation method is simple and convenient in production process, good in stability and highin safety, and the product quality is convenient to control.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to an improved preparation method of Chuanxiong tea medicinal composition. Background technique [0002] Chuanxiong Chatiao Dripping Pills, a product of Guizhou Jianxing Pharmaceutical Co., Ltd., are effective in dispelling wind and relieving pain. It is used for headache due to wind pathogens, or chills, fever, and nasal congestion; it is good at treating Shaoyang and Jueyin headaches, and it is also used for migraines, nervous headaches, or headaches caused by traumatic sequelae, and insufficient blood supply to the brain; Higher quality, better drug efficacy, after our long-term quality control testing and combined research on the production process, we found that the products produced by the current production process have low content of active ingredients, and the appearance of the dripping pills is not round, easy to stick, dissolve Problems such as long dispersion time. ...

Claims

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Application Information

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IPC IPC(8): A61K36/538A61P25/00A61P29/00A61P11/02A61P25/06A61P9/10A61P25/04
CPCA61K36/232A61K36/236A61K36/237A61K36/238A61K36/268A61K36/484A61K36/534A61K36/538A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61P9/10A61P11/02A61P25/00A61P25/04A61P25/06A61P29/00A61K2300/00
Inventor 孙小鹦廖萍廖伟廖忠
Owner 贵州健兴药业有限公司
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