Pharmaceutical composition for preventing or treating ischemia/reperfusion injury and application

A technology of reperfusion injury and composition, applied in the field of biomedicine, can solve unconsidered problems, achieve the effect of less irritation, reduce disability rate, and enhance compliance

Active Publication Date: 2021-03-19
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The applicant previously found that echinocandin drugs such as micafungin and caspofungin can be used to treat ischemia / reperfusion injury, but did not consider combining with other active ingredients to obtain better effects

Method used

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  • Pharmaceutical composition for preventing or treating ischemia/reperfusion injury and application
  • Pharmaceutical composition for preventing or treating ischemia/reperfusion injury and application
  • Pharmaceutical composition for preventing or treating ischemia/reperfusion injury and application

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Embodiment Construction

[0039] The present invention will be described in detail below with reference to the accompanying drawings and examples. It should be noted that, in the case of no conflict, the embodiments of the present invention and the features in the embodiments can be combined with each other.

[0040] Hereinafter, the amount of enlicasen and the amount of caspofungin are expressed as a certain ratio of enlicasen and caspofungin.

[0041] Animal experiment: the protective effect of the combination of Enlikagen and Caspofungin on ischemic stroke.

[0042] Experimental animals: 48 healthy male SD rats with a body weight of 250-300 g. The experimental animals were fed for one week in an environment with a temperature of 25° C., a relative humidity of 60%, free access to drinking water, and regular and quantitative amounts, and then administered orally according to the requirements of each group in the experiment.

[0043]Modeling method: The rat model of cerebral ischemia / reperfusion inju...

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Abstract

The invention relates to a pharmaceutical composition for preventing or treating ischemia / reperfusion injury and application. The pesticidal composition comprises an active component, wherein the active component is composed of an active ingredient A and an active ingredient B, the active ingredient A is Emricasan or pharmaceutically acceptable salts thereof, the active ingredient B comprises Echinocandin drugs or pharmaceutically acceptable salts thereof, and the weight ratio of the active ingredient A to the active ingredient B is 1: (0.1 to 10). The pharmaceutical composition disclosed by the invention can be used for preventing and / or treating the ischemia / reperfusion injury in a synergistic manner, particularly treating nerve cell injury, more particularly plays a role in protecting ischemic cerebral apoplexy and can be used for remarkably alleviating cerebral ischemia / reperfusion injury.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing or treating ischemia / reperfusion injury and its application, belonging to the field of biomedicine. Background technique [0002] Ischemic stroke is a common and frequently-occurring disease that seriously endangers human health. It has become the first cause of disability and the third cause of death in the world. The incidence of ischemic stroke accounts for about 70-80% of cerebrovascular diseases. [0003] Cerebral ischemic injury is related to multiple mechanisms such as excessive formation of free radicals, excitatory amino acid toxicity, intracellular calcium overload, and inflammatory response. Regardless of the mechanism, the final outcome will lead to neuronal cell death, functional destruction, and cerebral infarction form. There are two main ways of cell death, apoptosis and necrosis. Neuronal apoptosis and necrosis exist simultaneously in cerebral ischemic injury. The ...

Claims

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Application Information

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IPC IPC(8): A61K38/12A61P9/10A61K38/05
CPCA61K38/05A61K38/12A61K9/0019A61P9/10A61K2300/00
Inventor 罗秀菊彭军张议月彭紫梅刘斌
Owner CENT SOUTH UNIV
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