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Application of dronedarone in the preparation of drugs for preventing and treating colitis

A technology for dronedarone and colitis, applied in the field of medicine

Active Publication Date: 2022-04-12
THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the application of dronedarone in the treatment of colitis

Method used

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  • Application of dronedarone in the preparation of drugs for preventing and treating colitis
  • Application of dronedarone in the preparation of drugs for preventing and treating colitis
  • Application of dronedarone in the preparation of drugs for preventing and treating colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Study on the therapeutic effect of dronedarone on dextran sulfate sodium salt (DSS)-induced ulcerative colitis mice

[0025] 1. Modeling method of DSS-induced ulcerative colitis mice (DSS model mice)

[0026] Thirty-two C57 / 6J male mice weighing 20-25 g were randomly divided into 4 groups, 8 in each group, respectively control group, DSS modeling group (DSS), compound dronedarone group (DSS+DRO) and Positive control drug olsalazine group (DSS+OLZ). The mice in the control group drank normal water, the mice in the DSS modeling group, the compound dronedarone group and the positive control drug olsalazine group drank special drinking water containing 2.5% DSS for 7 consecutive days, and replaced the special drinking water every other day to induce the construction of mice Ulcerative colitis model.

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PUM

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Abstract

The invention belongs to the technical field of medicine, and specifically relates to the application of dronedarone in the preparation of drugs for preventing and treating colitis. In order to find out that new compounds appear to be used for the treatment of ulcerative colitis, the invention uses the compound dronedarone to treat DSS Therapeutic effect of induced ulcerative colitis in mice The study found that dronedarone has a therapeutic effect on DSS-induced ulcerative colitis in mice, and it is expected to be applied to the prevention and treatment of ulcerative colitis.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of dronedarone in the preparation of drugs for preventing and treating colitis. Background technique [0002] Dronedarone (DRO) is a new antiarrhythmic drug developed by Sanofi-Aventis in France, which was approved by the US FDA in July 2009 for atrial fibrillation and atrial flutter. (AF / AFL) antiarrhythmic drugs. It is an iodine-free benzofuran derivative. Its structure and pharmacological properties are similar to those of amiodarone, and it has no obvious thyroid inhibitory effect and thyroid hormone inhibitory effect, and has few adverse reactions. It has become a new generation of antiarrhythmic drugs. [0003] Inflammatory bowel disease (Inflammatory bowel disease, IBD) is an idiopathic intestinal inflammatory disease involving the ileum, colon, and rectum, including ulcerative colitis (Ulcerative colitis, UC) and Crohn's disease (Crohn's dise...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/343A61P1/00A61P1/04
CPCA61K31/343A61P1/00A61P1/04
Inventor 刘焕亮张瀞丹张敏陈骏雄李伟倩王子涵杨湘玲
Owner THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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