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Application of mimics of manganese superoxide dismutase (MnSODm) in preparation of ulcerative colitis (UC) treatment medicine

A technology for ulcerative colitis and superoxide, applied in the field of medicine

Inactive Publication Date: 2015-04-08
甘肃省人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Our previous research results found that MnSODm has strong antioxidant, oxygen free radical scavenging and anti-inflammatory activities, and it has obvious protective effects on carbon tetrachloride-induced acute liver injury in mice, while MnSODm has a significant effect on rat ulcer Whether there is a therapeutic effect on chronic colitis has not yet been reported

Method used

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  • Application of mimics of manganese superoxide dismutase (MnSODm) in preparation of ulcerative colitis (UC) treatment medicine
  • Application of mimics of manganese superoxide dismutase (MnSODm) in preparation of ulcerative colitis (UC) treatment medicine
  • Application of mimics of manganese superoxide dismutase (MnSODm) in preparation of ulcerative colitis (UC) treatment medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Embodiment 1, the preparation of capsule medicine

[0066] Raw material ratio: MnSODm 200 mg, appropriate amount of 10% starch slurry, appropriate amount of food coloring;

[0067] Preparation process: After MnSODm passes through a 80-mesh sieve, add 10% starch, food coloring and appropriate amount of water, mix evenly, make a soft material, pass through a 14-mesh nylon sieve to granulate, dry at 70°C until the water content is below 3%, and fill into empty capsules In total, 100 hard capsules were made;

[0068] Dosage: 2 times a day, 1 capsule each time.

Embodiment 2

[0069] Embodiment 2, the preparation of granule medicine

[0070] Raw material ratio: MnSODm 200 mg, powdered sugar 500 g, starch 500 g;

[0071] Preparation process: After sieving MnSODm, add starch, sugar powder and appropriate amount of water to MnSODm, mix evenly, make soft material, pass through a 14-mesh nylon sieve to granulate, dry the wet granules at 60°C, and pass the dry granules through a 14-mesh sieve for granulation , and then pass through a No. 4 sieve (65 mesh) to remove fine powder, then pack, seal, and pack. Specification: 2mg / 10g;

[0072] Dosage: 2 times a day, 1 bag each time.

Embodiment 3

[0073] Embodiment 3, the preparation of injection

[0074] Raw material ratio: MnSODm 200 mg, sodium chloride 850 mg, Tween 1 mL, water for injection to 100 mL;

[0075] Preparation process: In a preparation container, add 80% of the prescription amount of water for injection, add 200 mg of MnSODm, sodium chloride and Tween, stir to dissolve completely, filter, pot, and sterilize at 100°C for 30 minutes. Specification 2mg / 1mL;

[0076] Dosage: 2 times a day, 1 bottle at a time.

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Abstract

The invention provides a new medical use of mimics of manganese superoxide dismutase (MnSODm), namely an application in the preparation of an ulcerative colitis (UC) treatment medicine. Observation on the treatment effect of the MnSODm compound on the 2,4,6-trinitrobenzene sulfonic acid (TNBS) induced rat UC indicates that the MnSODm has an obvious treatment effect on the TNBS induced rat UC; and therefore, the MnSODm can be used for preparing UC treatment medicines, namely that the MnSODm is made into pharmaceutically acceptable preparations by taking the MnSODm as an active ingredient according to conventional processes and accessories.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a new medicine application of a manganese superoxide dismutase mimic (MnSODm) in the preparation of medicines for treating ulcerative colitis. Background technique [0002] Ulcerative colitis (UC), also known as nonspecific ulcerative colitis, is a chronic inflammatory disease of the rectum and colon of unknown cause. The lesions are mainly located in the mucosal layer of the colon, and are mainly ulcers, mostly involving the rectum and distal colon, and can also spread throughout the colon. In recent years, with the continuous improvement of people's living standards, changes in diet structure, increased work pressure, and accelerated pace of life, the incidence of UC has increased year by year. The disease is related to the onset of colon cancer, and the course of the disease is long and the severity of the lesion varies. Because the etiology is unknown, it often manifests as r...

Claims

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Application Information

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IPC IPC(8): A61K31/28A61P1/04
CPCA61K9/0019A61K9/0053A61K9/08A61K9/1652A61K9/2031A61K31/28A61K47/26
Inventor 李红玲王艳红
Owner 甘肃省人民医院
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