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Examples
Experimental program
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Effect test
Embodiment 1
[0065] Embodiment 1, the preparation of capsule medicine
[0067] Preparation process: After MnSODm passes through a 80-mesh sieve, add 10% starch, food coloring and appropriate amount of water, mix evenly, make a soft material, pass through a 14-mesh nylon sieve to granulate, dry at 70°C until the water content is below 3%, and fill into empty capsules In total, 100 hard capsules were made;
[0068] Dosage: 2 times a day, 1 capsule each time.
Embodiment 2
[0069] Embodiment 2, the preparation of granule medicine
[0071] Preparation process: After sieving MnSODm, add starch, sugarpowder and appropriate amount of water to MnSODm, mix evenly, make soft material, pass through a 14-mesh nylon sieve to granulate, dry the wet granules at 60°C, and pass the dry granules through a 14-mesh sieve for granulation , and then pass through a No. 4 sieve (65 mesh) to remove fine powder, then pack, seal, and pack. Specification: 2mg / 10g;
[0072] Dosage: 2 times a day, 1 bag each time.
Embodiment 3
[0073] Embodiment 3, the preparation of injection
[0074] Raw material ratio: MnSODm 200 mg, sodiumchloride 850 mg, Tween 1 mL, water for injection to 100 mL;
[0075] Preparation process: In a preparation container, add 80% of the prescription amount of water for injection, add 200 mg of MnSODm, sodiumchloride and Tween, stir to dissolve completely, filter, pot, and sterilize at 100°C for 30 minutes. Specification 2mg / 1mL;
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Abstract
The invention provides a new medical use of mimics of manganesesuperoxidedismutase (MnSODm), namely an application in the preparation of an ulcerative colitis (UC) treatment medicine. Observation on the treatment effect of the MnSODm compound on the 2,4,6-trinitrobenzene sulfonic acid (TNBS) induced rat UC indicates that the MnSODm has an obvious treatment effect on the TNBS induced rat UC; and therefore, the MnSODm can be used for preparing UC treatment medicines, namely that the MnSODm is made into pharmaceutically acceptable preparations by taking the MnSODm as an active ingredient according to conventional processes and accessories.
Description
technical field [0001] The invention belongs to the technical field of medicine, and relates to a new medicine application of a manganesesuperoxidedismutase mimic (MnSODm) in the preparation of medicines for treating ulcerative colitis. Background technique [0002] Ulcerative colitis (UC), also known as nonspecific ulcerative colitis, is a chronic inflammatory disease of the rectum and colon of unknown cause. The lesions are mainly located in the mucosal layer of the colon, and are mainly ulcers, mostly involving the rectum and distal colon, and can also spread throughout the colon. In recent years, with the continuous improvement of people's living standards, changes in diet structure, increased work pressure, and accelerated pace of life, the incidence of UC has increased year by year. The disease is related to the onset of colon cancer, and the course of the disease is long and the severity of the lesion varies. Because the etiology is unknown, it often manifests as r...
Claims
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