Pharmaceutical composition for treating myocardial ischemia as well as application of pharmaceutical composition and injection prepared and formed by pharmaceutical composition

A technique for myocardial ischemia and composition, applied in the field of pharmaceutical compositions and their applications and injections prepared therefrom, can solve problems such as difficulty in meeting quality requirements, inability to guarantee medication safety, unclear active ingredients, etc. Clear, safe medication, clear ingredients

Inactive Publication Date: 2018-01-12
朗致集团江西医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, the technical problem to be solved by the present invention is to overcome the defect that the Ginkgo biloba extract and its preparations prepared by the prior art are difficult to meet the quality requirements and cannot guarantee the safety of medication, and the unclear active ingredients lead to inaccurate curative effect, and then provide a New Ginkgo Biloba Extract Formulation and Injectables Formed Therefrom for the Treatment of Myocardial Ischemia

Method used

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  • Pharmaceutical composition for treating myocardial ischemia as well as application of pharmaceutical composition and injection prepared and formed by pharmaceutical composition
  • Pharmaceutical composition for treating myocardial ischemia as well as application of pharmaceutical composition and injection prepared and formed by pharmaceutical composition
  • Pharmaceutical composition for treating myocardial ischemia as well as application of pharmaceutical composition and injection prepared and formed by pharmaceutical composition

Examples

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Comparison scheme
Effect test

Embodiment 1

[0034]The present invention provides a kind of preparation method containing the injection of the pharmaceutical composition for treating myocardial ischemia, comprising the following steps:

[0035] (1) After getting Ginkgo biloba pulverization, add 95% ethanol and reflux extraction 3 times, each reflux extraction time is 0.5 hour, the quality that adds 95% ethanol at every turn is 10 times of Ginkgo leaf quality; Filter, gained filtrate decompression Concentrate to 0.2 times the mass of Ginkgo biloba, refrigerate for 48 hours;

[0036] (2) Scrape off the slick oil and take off the lower layer liquid;

[0037] (3) Add water for injection to 0.5 times of the quality of ginkgo leaves in the lower layer liquid, and refrigerate for 48 hours; filter, concentrate the filtrate under reduced pressure to 0.2 times of the quality of ginkgo leaves, put to room temperature, add 95% ethanol, make the alcohol content to 82%, the solution after alcohol precipitation was refrigerated, filte...

Embodiment 2

[0042] The present invention provides a kind of preparation method containing the injection of the pharmaceutical composition for treating myocardial ischemia, comprising the following steps:

[0043] (1) After getting Ginkgo biloba and pulverizing, add 96% ethanol and reflux extraction 1 time, each reflux extraction time is 0.4 hour, the quality of adding 96% ethanol at every turn is 11 times of Ginkgo biloba quality; Filter, gained filtrate is decompressed Concentrate to 0.15 times the mass of Ginkgo biloba, refrigerate for 52 hours;

[0044] (2) Scrape off the slick oil and take off the lower layer liquid;

[0045] (3) Add water for injection to 0.65 times of the quality of ginkgo leaves in the lower layer liquid, and refrigerate for 47 hours; filter, concentrate the filtrate under reduced pressure to 0.1 times of the quality of ginkgo leaves, put it to room temperature, add 96% ethanol to increase the alcohol content to 83%, the solution after alcohol precipitation was re...

Embodiment 3

[0050] The present invention provides a kind of preparation method containing the injection of the pharmaceutical composition for treating myocardial ischemia, comprising the following steps:

[0051] (1) After getting Ginkgo biloba and pulverizing, add 93% ethanol and reflux extraction 2 times, each reflux extraction time is 0.3 hour, the quality that adds 93% ethanol at every turn is 12 times of Ginkgo leaf quality; Filter, gained filtrate is decompressed Concentrate to 0.1 times the mass of ginkgo biloba, refrigerate for 47 hours;

[0052] (2) Scrape off the slick oil and take off the lower layer liquid;

[0053] (3) Add water for injection to 0.45 times of the quality of ginkgo leaves in the lower layer liquid, and refrigerate for 52 hours; filter, concentrate the filtrate under reduced pressure to 0.15 times of the quality of ginkgo leaves, put to room temperature, add 93% ethanol, make the alcohol content to 79%, the solution after alcohol precipitation was refrigerated...

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Abstract

The invention belongs to the field of pharmaceutical compositions, and in particular relates to a pharmaceutical composition for treating myocardial ischemia as well as an application of the pharmaceutical composition and an injection prepared and formed by the pharmaceutical composition. The pharmaceutical composition consists of quercetin-3-O-[beta]-D-glucosyl (1-2)-[alpha]-L-rhamnoside, narcissoside, kaempferol-3-O-[beta]-D-glucosyl (1-2)-[alpha]-L-rhamnoside and ginkgolides A, B and C. The pharmaceutical composition is clear in ingredients and controllable in mass; the various components are mutually cooperated under specific proportions; and the pharmaceutical composition can be clinically applied to myocardial ischemia, with a curative effect obviously better than that of a ginkgo biloba extract, which is unclear in components, provided by the prior art. The invention also provides a preparation method of pharmaceutical composition; by conducting reflux extraction with 93-96% ethanol, and by implementing porous resin adsorption treatment, the components can be effectively separated; and the preparation method is simple in process and applicable to industrial production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compositions, and in particular relates to a pharmaceutical composition for treating myocardial ischemia, an application thereof and an injection prepared therefrom. Background technique [0002] Ginkgo biloba L., also known as ginkgo (seed), ginkgo tree, gongsun tree, moth leaf, duck foot, is a deciduous tree of the genus Ginkgo in the family Ginkgoaceae, belonging to ancient and rare plants , has the laudatory title of "living fossil" and "panda in the plant kingdom". Ginkgo biloba is the dry leaves of Ginkgo biloba, harvested in autumn when the leaves are still green. It is sweet, bitter, astringent, flat in nature, returns to the heart and lung meridian, has the functions of promoting blood circulation and removing blood stasis, dredging collaterals and relieving pain, astringing the lungs and relieving asthma, reducing turbidity and reducing fat. It is used to treat blood stasis blocking collat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/365A61K9/08A61P9/10A21D13/06A23L2/52A23L33/105A23L33/10A23G3/42A23G3/48
Inventor 王锋杨满辉
Owner 朗致集团江西医药有限公司
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