Application of pyrroloquinoline quinone or salt thereof in preparation of medicines for preventing and treating benign prostatic hyperplasia, and pharmaceutical composition
A technology of pyrroloquinoline quinone and benign prostatic hyperplasia, which is applied in the field of medicine, can solve the problems of reduced curative effect, achieve good inhibitory effect, reduce the prostate index, and improve the effect of SOD activity
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[0023] Prevention and treatment of pyrroloquinoline quinone disodium salt on testosterone propionate-induced benign prostatic hyperplasia.
[0024] 1. Experimental materials
[0025] 1.1 Experimental animals
[0026] SPF-ICR mice (old group: 8 months old, body weight 40-57g; young group: 8 weeks old, body weight 30-40g) were provided by the Experimental Animal Center of Nantong University, certificate number: SCXK (Su) 2014-0001.
[0027] 1.2 Drugs and reagents
[0028] The positive drug finasteride (5mg / tablet, Hangzhou MSD Pharmaceutical Co., Ltd.), the dosage is 1.67mg / kg, which is 20 times of the clinical human dosage (5mg / 60kg).
[0029] Pyrroloquinoline quinone disodium salt (Sigma), the dosage is 10 mg / kg, 1 mg / kg.
[0030] Experimental feed: full price nutrient pellet feed (Nanjing Synergy Animal Feed Factory).
[0031] The superoxide dismutase (SOD) kit and malondialdehyde (MDA) kit (Nanjing Jiancheng Bioengineering Institute) were used for determination according...
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