Multi-stage reaction micro-channel structure, micro-fluidic chip and heterogeneous reaction method

Abstract

The invention provides a multi-stage reaction micro-channel structure, a micro-fluidic chip and a heterogeneous reaction method. The multi-stage reaction micro-channel structure comprises a continuous outer triangular expansion focusing unit, an active valve quantitative uniform control unit and a multi-stage heterogeneous reaction tank unit, the continuous outer triangular expansion focusing unit comprises a continuous outer triangular expansion focusing flow channel and a continuous liquid phase flow channel; the active valve quantitative uniform control unit comprises a first active valve, a second active valve and a third active valve; the first active valve comprises a built-in valve plug, a gas phase channel and a gas buffer chamber; a built-in valve plug is arranged on the inner wall of the continuous liquid phase flow channel; and the multi-stage heterogeneous reaction tank unit comprises a first-stage heterogeneous reaction tank unit and a second-stage heterogeneous reaction tank unit. The invention solves the technical problems of how to design a microfluidic device and an operation process, so that on the basis of generating high-dispersion liquid drops and particles, the microfluidic device and the operation process can realize rapid and accurate quantitative control to carry out accurate and efficient heterogeneous reaction and improve the sufficiency of the reaction.

Description

technical field

[0001] The present application relates to the field of microfluidic technology, in particular to a multi-stage reaction microfluidic channel structure, a microfluidic chip and a heterogeneous reaction method. Background technique

[0002] With the development of science and technology, more and more fields (energy, immunity, biochemistry, etc.) need to use miniaturized reaction methods for highly dispersed micro-precision operations. Microfluidic technology can achieve many difficult-to-complete micro-processing and micro-operations. has received widespread attention. Microfluidics is the use of microchannels and devices to manipulate tiny particles (or samples) that cannot be achieved by conventional methods. It can integrate biological detection, a series of biochemical reactions, and various sample preparations into tiny chips for special operations, and has broad application prospects in many fields.

[0003] At present, the conventional preparation pro...

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