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Multi-stage reaction micro-channel structure, micro-fluidic chip and heterogeneous reaction method

A multi-stage reaction and microfluidic technology, applied in the field of microfluidics, can solve problems such as difficult quantitative control

Pending Publication Date: 2021-05-07
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the dispersion of droplets (or particles) can be achieved to a certain extent, a certain length of spiral curved flow path is required to achieve the goal, and it is difficult to perform precise quantitative control

Method used

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  • Multi-stage reaction micro-channel structure, micro-fluidic chip and heterogeneous reaction method
  • Multi-stage reaction micro-channel structure, micro-fluidic chip and heterogeneous reaction method
  • Multi-stage reaction micro-channel structure, micro-fluidic chip and heterogeneous reaction method

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Embodiment 2

[0111] The above is the embodiment one provided by the application, and the following is the embodiment two provided by the application, specifically:

[0112] The material of the chip body is PDMS (polydimethylsiloxane), in which the length of the continuous outer triangular expansion focusing channel is 1200 mm, the distance between two adjacent vortex focusing channels is 100 μm, and the radius of curvature of the innermost channel is 40 mm. The width of the flow channel, the first reaction liquid phase flow channel, the continuous liquid phase flow channel and the second reaction liquid flow channel is 100 μm, the width of the first liquid outlet flow channel and the second liquid outlet flow channel is 100 μm, and the gas buffer chamber is The distance from the continuous liquid phase flow channel in non-working state is 60 μm, and the height of all flow channels is 150 μm. Nitrogen is selected as the gas phase, and an appropriate amount of carbon spheres with a particle ...

Embodiment 3

[0113] The above is the second embodiment provided by the application, and the following is the third embodiment provided by the application, specifically:

[0114] The material of the chip body is PDMS, in which the length of the continuous outer triangular expansion focusing channel is 1600mm, the distance between two adjacent vortex focusing channels is 80μm, the radius of curvature of the innermost channel is 50mm, the gas phase channel, the first reaction liquid phase flow The width of the channel, the continuous liquid phase channel and the second reaction liquid channel is 120 μm, the width of the mixed liquid phase channel and the liquid outlet channel is 160 μm, and the gas buffer chamber is kept in the non-working state with the wall of the liquid phase channel. A certain distance is 80 μm, and the height of all flow channels is 200 μm. Nitrogen is selected as the gas phase, and an appropriate amount of carbon spheres with a particle size of 50 μm is added to the mix...

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Abstract

The invention provides a multi-stage reaction micro-channel structure, a micro-fluidic chip and a heterogeneous reaction method. The multi-stage reaction micro-channel structure comprises a continuous outer triangular expansion focusing unit, an active valve quantitative uniform control unit and a multi-stage heterogeneous reaction tank unit, the continuous outer triangular expansion focusing unit comprises a continuous outer triangular expansion focusing flow channel and a continuous liquid phase flow channel; the active valve quantitative uniform control unit comprises a first active valve, a second active valve and a third active valve; the first active valve comprises a built-in valve plug, a gas phase channel and a gas buffer chamber; a built-in valve plug is arranged on the inner wall of the continuous liquid phase flow channel; and the multi-stage heterogeneous reaction tank unit comprises a first-stage heterogeneous reaction tank unit and a second-stage heterogeneous reaction tank unit. The invention solves the technical problems of how to design a microfluidic device and an operation process, so that on the basis of generating high-dispersion liquid drops and particles, the microfluidic device and the operation process can realize rapid and accurate quantitative control to carry out accurate and efficient heterogeneous reaction and improve the sufficiency of the reaction.

Description

technical field [0001] The present application relates to the field of microfluidic technology, in particular to a multi-stage reaction microfluidic channel structure, a microfluidic chip and a heterogeneous reaction method. Background technique [0002] With the development of science and technology, more and more fields (energy, immunity, biochemistry, etc.) need to use miniaturized reaction methods for highly dispersed micro-precision operations. Microfluidic technology can achieve many difficult-to-complete micro-processing and micro-operations. has received widespread attention. Microfluidics is the use of microchannels and devices to manipulate tiny particles (or samples) that cannot be achieved by conventional methods. It can integrate biological detection, a series of biochemical reactions, and various sample preparations into tiny chips for special operations, and has broad application prospects in many fields. [0003] At present, the conventional preparation pro...

Claims

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Application Information

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IPC IPC(8): B01J19/00B01J4/02B01J4/00B01L3/00
CPCB01J19/0093B01J19/0053B01J4/02B01J4/008B01L3/502738
Inventor 王超蒋志强李嘉辉
Owner GUANGDONG UNIV OF TECH
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