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Colloidal bismuth pectin preparation for treating superficial gastritis and preparation method thereof

A technology of colloidal bismuth pectin and pectin, which is applied to medical preparations, pharmaceutical formulations, organic active ingredients and other directions containing active ingredients, can solve the problems of bismuth poisoning and large dosage, and achieves prevention of bismuth poisoning, increasing affinity, Strong adsorption effect

Active Publication Date: 2022-02-11
黑龙江迪龙制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problem that large doses of colloidal bismuth pectin can easily cause bismuth poisoning, the invention provides a colloidal bismuth pectin compound preparation for treating superficial gastritis and a preparation method thereof

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] The present embodiment provides a kind of preparation method of nano-colloid bismuth pectin, comprising the following steps:

[0059] Step 1. Prepare the following components by weight: 10-15 parts of bismuth nitrate pentahydrate, 5-7 parts of sorbitol, 20-30 parts of pectin, 3-5 parts of disintegrant, and 2-3 parts of binder ;

[0060] Step 2: Add bismuth nitrate pentahydrate into sorbitol and stir well, add 20-30 parts of deionized water and continue to stir until the obtained mixed solution is clear; add potassium hydroxide dropwise to the obtained clear mixed solution under stirring , as the pH of the solution rises, a white flocculent precipitate begins to form, and when the pH reaches 7.0, the white precipitate completely precipitates and does not increase any more; add 100 parts of deionized water, stir for 5 minutes, let it stand for stratification, and discard the supernatant after 2 hours , collect the white precipitate in the lower layer, add 100 parts of de...

Embodiment 2

[0065] The present embodiment provides a kind of preparation method of colloidal bismuth pectin nanoscale compound preparation, comprising the steps:

[0066] Step 1. Prepare the following components by weight: 10-15 parts of bismuth nitrate pentahydrate, 5-7 parts of sorbitol, 20-30 parts of pectin, 3-5 parts of Smilax smilax, 2-3 parts of raw licorice, honeysuckle 2-3 parts, 2-3 parts of dandelion, 3-5 parts of disintegrant, 2-3 parts of adhesive;

[0067] Step 2: Add bismuth nitrate pentahydrate into sorbitol and stir well, add 20-30 parts of deionized water and continue to stir until the obtained mixed solution is clear; add potassium hydroxide dropwise to the obtained clear mixed solution under stirring , as the pH of the solution rises, a white flocculent precipitate begins to form, and when the pH reaches 7.0, the white precipitate completely precipitates and does not increase any more; add 100 parts of deionized water, stir for 5 minutes, let it stand for stratificatio...

Embodiment 3

[0072] The present embodiment provides a kind of preparation method of colloidal bismuth pectin nanoscale compound preparation, comprising the steps:

[0073] Step 1. Prepare the following components by weight: 10-15 parts of bismuth nitrate pentahydrate, 5-7 parts of sorbitol, 20-30 parts of pectin, 3-5 parts of Smilax smilax, 2-3 parts of raw licorice, honeysuckle 2-3 parts, 2-3 parts of dandelion, 3-5 parts of disintegrant, 2-3 parts of adhesive;

[0074] Step 2: Dried Smilax smilax, raw licorice, honeysuckle and dandelion at 60-70°C for 6 hours, then crushed to 50 mesh to obtain mixed Chinese medicine powder, added 10 times the volume of water to decoct for 3 hours, collected the decoction liquid, and added to the remaining Chinese medicine dregs decoct 8 times the volume of water for 3 hours, collect and combine the decoction liquid, and concentrate the combined decoction liquid under reduced pressure to obtain the active ingredient concentrate of traditional Chinese medi...

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Abstract

The invention relates to a colloidal bismuth pectin preparation for treating superficial gastritis and a preparation method thereof, belonging to the technical field of pharmacy. In order to solve the problem that large doses of colloidal bismuth pectin are likely to cause bismuth poisoning, the present invention provides a colloidal pectin bismuth compound preparation for treating superficial gastritis and a preparation method thereof, including nano Colloidal bismuth pectin particles, micron-sized colloidal bismuth pectin particles loaded with soil tuckahoe, raw licorice, honeysuckle and dandelion, nano-sized colloidal bismuth pectin particles loaded with active ingredients of traditional Chinese medicine, and core-shell structure loaded with active ingredients of traditional Chinese medicine Colloidal bismuth pectin particles. The colloidal protective film formed by the colloidal bismuth pectin preparation provided by the invention has strong adsorption and stability, and can reduce the dosage of colloidal bismuth pectin; at the same time, the Chinese medicine components can detoxify and reduce inflammation, help the body to expel bismuth as soon as possible, and avoid taking colloidal bismuth pectin. The occurrence of bismuth poisoning caused by colloidal bismuth.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a colloidal bismuth pectin preparation for treating superficial gastritis and a preparation method thereof. Background technique [0002] Chronic superficial gastritis is a disease of chronic superficial inflammation of the gastric mucosa. It is a common disease of the digestive system and belongs to chronic gastritis. It can be caused by alcoholism, strong coffee, bile reflux, or Helicobacter pylori infection. Patients may have different degrees of indigestion symptoms, such as upper abdominal discomfort and dull pain after eating, accompanied by belching, nausea, pantothenic acid, and occasionally vomiting. [0003] Colloidal bismuth pectin is an indeterminate complex of pectin and bismuth, which can form a stable colloidal dispersion in water, and is a commonly used gastrointestinal mucosal protective drug. After oral administration, a sol is formed in the acidi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/245A61K31/732A61K36/896A61K36/90A61P1/04A61K9/16A61K31/047
CPCA61K31/047A61K31/732A61K36/90A61K36/896A61K36/484A61K36/355A61K36/288A61K9/167A61K9/1694A61P1/04A61K2300/00
Inventor 董继胜杨久春于芳王永义胡国庆
Owner 黑龙江迪龙制药有限公司
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