The oral intestinal positioning 
delivery system for the health factors is specially designed for the health factors which are not suitable for direct oral eating and poor in stability and are required by human bodies, the oral intestinal positioning 
delivery system comprises a carrier prepared from 
sodium alginate and low-ester 
pectin and the health factors, and the M / G block ratio of the 
sodium alginate is 1: 2. A preparation method of the oral intestinal positioning 
delivery system for the health factors comprises the following steps: (1) mixing 
sodium alginate and a low-ester 
pectin solution according to a volume ratio of 1: 8-4: 1, and (2) adding a health factor solution into the 
carrier solution and mixing; and (3) uniformly mixing the 
mixed solution in the step (2) with a 
calcium chloride solution, filtering, washing, 
drying at 
room temperature to obtain target carrier beads, and storing at 4 DEG C. According to the present invention, the design is scientific and reasonable, the compact gel network is achieved, the health factors are densely intercepted in the gel, the carrier efficiently passes through the 
stomach environment to directly reach the 
small intestine, the colon and other parts, and the health factors not suitable for direct 
oral administration have the 
oral administration possibility; a new way is provided for simple, efficient and noninvasive utilization of health factors with low stability and low 
bioavailability, no additional chemical 
reagent is added in the preparation method, the process is simple and green, and experimental 
verification shows that one or more hydrophilic and / or hydrophobic health factors can be delivered respectively or simultaneously.