Health factor oral intestinal positioning delivery system and preparation method

Abstract

The oral intestinal positioning delivery system for the health factors is specially designed for the health factors which are not suitable for direct oral eating and poor in stability and are required by human bodies, the oral intestinal positioning delivery system comprises a carrier prepared from sodium alginate and low-ester pectin and the health factors, and the M / G block ratio of the sodium alginate is 1: 2. A preparation method of the oral intestinal positioning delivery system for the health factors comprises the following steps: (1) mixing sodium alginate and a low-ester pectin solution according to a volume ratio of 1: 8-4: 1, and (2) adding a health factor solution into the carrier solution and mixing; and (3) uniformly mixing the mixed solution in the step (2) with a calcium chloride solution, filtering, washing, drying at room temperature to obtain target carrier beads, and storing at 4 DEG C. According to the present invention, the design is scientific and reasonable, the compact gel network is achieved, the health factors are densely intercepted in the gel, the carrier efficiently passes through the stomach environment to directly reach the small intestine, the colon and other parts, and the health factors not suitable for direct oral administration have the oral administration possibility; a new way is provided for simple, efficient and noninvasive utilization of health factors with low stability and low bioavailability, no additional chemical reagent is added in the preparation method, the process is simple and green, and experimental verification shows that one or more hydrophilic and / or hydrophobic health factors can be delivered respectively or simultaneously.

Description

technical field [0001] The invention belongs to the field of functional food, and relates to a health factor embedding technology, in particular to a health factor oral intestinal positioning delivery system and a preparation method. Background technique [0002] The human body needs to supplement a certain amount of health factors every day in order to play a good role in health care. Most of the health factors such as polyphenols, vitamins, and saponins are directly affected by the strong acid environment (pH 1.2) in the stomach, and are metabolized rapidly in the body, which greatly reduces their absorption efficiency and bioavailability, making it difficult to exert their full potential. Due to its original health benefits, it is not suitable for direct oral consumption. At present, food-grade gels based on polysaccharides and / or proteins, which are widely distributed in nature, have various types, and have the characteristics of biodegradability, biocompatibility, safe...

AI Technical Summary

Problems solved by technology

[0004] Carriers based on sodium alginate and / or pectin disclosed in scientific and patent literature so far usually have one or more of the following defects: ①Most health products appear in the form of capsules, which are swallowed directly and have poor taste ; ②The embedding rate of health factors is low, and it is impossible to load a large amount of drugs in an appropriate amount, which leads to an increase in the consumption of health care products each time; ③A variety of chemical agents are added in the preparation process, which is harmful to the human body if taken for a long time; ④The preparation process is complicated; ⑤Transportation Poor stability, many health factors are lost during transportation, and the actual active ingredients are greatly reduced, resulting in poor bioavailability; ⑥ The type of health factors carried is single, and only one health factor can be transported at a time, or even only specific health factors

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