Preparation method of cannabidiol solid dispersion, prepared cannabidiol solid dispersion and application of cannabidiol solid dispersion

A technology of solid dispersion and cannabidiol, which is applied in medical preparations of non-active ingredients, skin care preparations, and functions of food ingredients, etc., can solve the problem of cannabidiol being insoluble in water and achieve good light transmittance , easy storage and transportation, good stability effect

Pending Publication Date:
View PDF14 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Aiming at the technical problems still existing in the above-mentioned prior art, the inventors found that by adopting the method for preparing cannabidiol solid dispersion described in this application, by dispersing cannabidiol in a water-soluble solid carrier and adding an emulsifier , promotes the dispersion of cannabidiol in the carrier, forms a dispersion at the molecular level, and then obtains a solid dispersion after cooling or drying, which can solve the problem of cannabidiol being insoluble in water and improve the solubility and bioavailability of cannabidiol

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Weigh 10g of cannabidiol crystals (purity 99%), melt them with 100g of PEG4000 and 50g of poloxamer 188 in a water bath at 70°C to become a homogeneous liquid, and place it directly in a -19°C refrigerator for 24 hours to obtain Solid Dispersion 1.

Embodiment 2

[0067] Weigh 20g of full-spectrum oil (CBD content 80%), 120g of PVP K30, 10g of Tween 80 and dissolve them in 200mL of absolute ethanol, dissolve evenly by ultrasonication, react at 60°C for 5h, and then dry the mixed solution under reduced pressure to obtain Cannabidiol solid dispersion 2, the prepared solid dispersion is ground into a powder product.

Embodiment 3

[0069] Weigh 20g of full-spectrum oil (CBD content 56%, CBDV content 40%) and dissolve it in 20mL of absolute ethanol, mix 120g of PEG4000 and PEG6000 at a ratio of 1:1, and melt 10g of Tween 80 together to form a homogeneous liquid at 80°C. Add the ethanol solution of cannabidiol into the molten liquid, mix evenly, evaporate the ethanol in a water bath at 80°C, then place the mixed solution in an ice-water bath, cool and solidify to obtain the solid dispersion 3.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
angle of reposeaaaaaaaaaa
Login to view more

Abstract

The invention provides a preparation method of a cannabidiol solid dispersion, the solid dispersion prepared by the method and an application of the solid dispersion, the cannabidiol solid dispersion is obtained by forming a molecular-level dispersion in a water-soluble solid carrier by using cannabidiol under the condition of adding an emulsifier, and then cooling or drying. The obtained solid dispersion can solve the problem that cannabidiol is insoluble in water, and the solubility and bioavailability of cannabidiol are improved. The cannabidiol solid dispersion is simple in preparation process and convenient for industrial production; and the application field of cannabidiol is expanded, and the obtained cannabidiol solid dispersion can also be used for foods, beverages and daily chemical products, and can also be combined with a steady-state technology as required during application.

Description

technical field [0001] The invention belongs to the field of preparation preparation and application, and relates to a preparation method of a cannabidiol solid dispersion with improved solubility, the cannabidiol solid dispersion prepared by the method and its application. Background technique [0002] Cannabidiol is a natural active ingredient from the stems, leaves, and seeds of the annual herb Cannabis genus Cannabis, which has a variety of pharmacological activities, and has anti-tumor effects, neuroprotective effects, metabolic and immune regulation effects, and cardiovascular protection. Anti-inflammatory and antioxidant effects, hepatoprotective and antibacterial effects. The numerous pharmacological effects of cannabidiol can be used in many aspects such as medicine, food, skin care products, health care products and pet products to exert its different effects. However, since cannabidiol is a fat-soluble substance, it is extremely difficult to dissolve in water. It...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/05A61K47/10A61K47/32A61K47/38A61P35/00A61P37/02A61P25/00A61K8/34A61K8/73A61K8/81A61K8/86A61K8/02A61Q19/00A23L2/39A23L2/52A23L33/105
CPCA61K9/145A61K9/146A61K31/05A61P35/00A61P37/02A61P25/00A61K8/86A61K8/8176A61K8/731A61K8/347A61K8/022A61Q19/00A23L2/39A23L2/52A23L33/105A23V2002/00A23V2200/30A23V2250/21A23V2250/2132
Inventor 焦丽娟高伟任婷婷徐建中
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap