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Poria cocos and semen cuscutae renal diabetes formula and application thereof

A technology of Futu and Shenxiao, which is applied in Futu Shenxiao formula and its application fields, and can solve problems such as the impact on liver and kidney functions, safety and effectiveness of unspecified traditional Chinese medicine compositions

Inactive Publication Date: 2021-06-29
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for this traditional Chinese medicine composition, its safety and effectiveness for treatment are doubtful: although domestic literature has not yet seen obvious toxicity reports for rhubarb, foreign academic journals have reported more about emodin and its anthraquinone in recent years. The nephrotoxicity and carcinogenicity of similar compounds; and the patent application does not give the experimental data and analysis of the effect of the traditional Chinese medicine composition on liver and kidney function. Therefore, the therapeutic effect of the above traditional Chinese medicine composition on diabetic nephropathy needs to be further explored

Method used

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  • Poria cocos and semen cuscutae renal diabetes formula and application thereof
  • Poria cocos and semen cuscutae renal diabetes formula and application thereof
  • Poria cocos and semen cuscutae renal diabetes formula and application thereof

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Embodiment 1

[0042] The main active ingredients of the Futu Shenxiao prescription in this embodiment include: Cuscuta 30g, Poria cocos 15g, Schisandra 10g, lotus seeds 15g, yam 20g, and trichosanthemi 15g in parts by weight.

[0043] The above-mentioned components are taken, and the traditional Chinese medicine decoction is prepared according to the existing preparation method of the traditional Chinese medicine decoction. The proportion is one dosage, and the dosage of one dosage is about 200mL.

[0044]The preparation method of the traditional Chinese medicine decoction is as follows: mix dodder, poria cocos, schisandra, lotus seeds, yam, and trichosanthemi in parts by weight to obtain a mixture, then add water to decoct for 2 hours according to a material-to-liquid ratio of 1:10, filter to obtain a filtrate, and cool to room temperature , and then carry out alcohol precipitation to the filtrate, the specific operation of alcohol precipitation is: add 95% edible ethanol to the traditional...

Embodiment 2

[0046] The main active ingredients of the Futu Shenxiao prescription in this embodiment include: Cuscuta 30g, Poria cocos 15g, Schisandra 10g, lotus seeds 15g, yam 20g, and trichosanthemi 15g in parts by weight.

[0047] The above-mentioned components are taken, and the traditional Chinese medicine decoction is prepared according to the existing preparation method of the traditional Chinese medicine decoction. The proportion is one dosage, and the dosage of one dosage is about 200mL.

[0048] The preparation method of the traditional Chinese medicine decoction is as follows: mix dodder, poria cocos, schisandra, lotus seeds, yam, and trichosanthemi in parts by weight to obtain a mixture, then add water to decoct for 1 hour according to the ratio of material to liquid at 1:10, filter to obtain the first filtrate, and The filter residue is decocted once, the filtrate obtained by filtering is combined with the first filtrate, sterilized, cooled to room temperature, and then the fil...

Embodiment 3

[0050] The main active ingredients of the Futu Shenxiao prescription in this embodiment include: Cuscuta 30g, Poria cocos 15g, Schisandra 10g, lotus seeds 15g, yam 20g, and trichosanthemi 15g in parts by weight.

[0051] The above components are taken, and the traditional Chinese medicine oral liquid is prepared according to the existing preparation method of the traditional Chinese medicine oral liquid. The proportion is one dose, and one dose is about 200 mL.

[0052] The preparation method of the traditional Chinese medicine oral liquid is as follows: mix dodder, poria cocos, schisandra, lotus seeds, yam, and trichosanthemi in parts by weight to obtain a mixture, then add water to decoct for 1.5 hours according to a material-to-liquid ratio of 1:15, and filter to obtain the first filtrate. Decoct the filter residue once, filter the obtained filtrate and combine the first filtrate, sterilize, cool to room temperature, and then carry out alcohol precipitation on the filtrate. ...

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Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a poria cocos and semen cuscutae renal diabetes formula and application thereof, and the poria cocos and semen cuscutae renal diabetes formula comprises the following main active ingredients in parts by weight: 10-60 parts of semen cuscutae, 10-60 parts of poria cocos, 5-30 parts of schisandra chinensis, 5-60 parts of lotus seeds, 10-60 parts of Chinese yam and 10-60 parts of radix trichosanthis. The invention further provides a preparation method and application of the poria cocos and semen cuscutae renal diabetes formula. Animal experiments show that the poria cocos and semen cuscutae renal diabetes formula can effectively improve obesity symptoms of mice with db / db2 type diabetic nephropathy, effectively reduce the blood fat level of the mice, especially effectively reduce the urine protein excretion rate of the mice, and has no damage to liver and renal functions of the mice. Under an electron microscope, it can be observed that foot process fusion in kidney podocytes of mice in a traditional Chinese medicine group is obviously improved, and it is indicated that the poria cocos and semen cuscutae renal diabetes formula has the kidney protection effect. Therefore, the poria cocos and semen cuscutae renal diabetes formula disclosed by the invention can be used for reducing proteinuria of diabetic nephropathy and playing a role in protecting kidneys by improving podocyte injury.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a Futushenxiao prescription and its application. Background technique [0002] Diabetic kidney disease (DKD) is one of the main microvascular complications of diabetes and has become the main cause of end-stage renal disease worldwide. Clinically, even if blood sugar and blood pressure are strictly controlled, some diabetic patients still have a large amount of refractory proteinuria, leading to a rapid decline in renal function. [0003] Recent studies have found that massive proteinuria in DKD is closely related to podocyte injury. In the early stage of DKD, podocytes will undergo pathological changes; as DKD progresses, podocytes will undergo apoptosis and shedding, which will damage the glomerular basement membrane and produce a large amount of proteinuria, prompting the development of DKD to end-stage renal disease. Traditional Chinese medicine has ...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P3/10A61P13/12
CPCA61K36/39A61K36/43A61K36/076A61K36/79A61K36/57A61K36/62A61K36/8945A61K36/428A61P3/10A61P13/12A61K2300/00
Inventor 张蕾刘旭生毛炜
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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