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Application of panax japonicus saponin IVa in preparation of drug for treating nephritis or renal fibrosis drug

A technology of ginseng saponins and renal fibrosis, which can be used in the preparation of drug combinations, steroids, and sugar derivatives, etc., and can solve the problems that the gradual progress of chronic kidney disease cannot be completely prevented.

Inactive Publication Date: 2018-05-25
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above-mentioned treatment methods can play a certain role in the treatment of renal fibrosis, they cannot completely prevent chronic kidney disease from gradually progressing to the end stage.

Method used

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  • Application of panax japonicus saponin IVa in preparation of drug for treating nephritis or renal fibrosis drug
  • Application of panax japonicus saponin IVa in preparation of drug for treating nephritis or renal fibrosis drug
  • Application of panax japonicus saponin IVa in preparation of drug for treating nephritis or renal fibrosis drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1 (preparation of bamboo ginseng saponin Ⅳa)

[0021] Take 20kg of Aralia taibai and add 10 times the volume concentration of 80% ethanol to reflux for extraction 3 times, reflux and extract at 80°C for 60min, concentrate under reduced pressure at 60°C to a relative density of 1.01-1.05 Aralia taibai crude extract; The product was dispersed with distilled water, extracted with chloroform 1:3 (v / v) to remove fat-soluble impurities, extracted 3 times with water-saturated n-butanol (1:3, v / v), combined the 3 extracts, and evaporated with rotary evaporator The instrument was recovered under reduced pressure at 60°C, and evaporated to dryness on a 60°C water bath. The n-butanol extract was separated by silica gel column chromatography, Sephadex LH-20 column chromatography, ODS reverse-phase column chromatography, Lobar column chromatography and reverse-phase HPLC preparation. Using 1D NMR (1H and 13C NMR), 2D NMR (DQCOSY, TOCSY, HMQC, HMBC, NOESY and ROESY) and M...

Embodiment 2

[0022] Embodiment 2 (capsules)

[0023] Weigh 10 mg of bamboo ginseng saponin IVa powder prepared in Example 1, 50-100 mg of starch, 50-70 mg of microcrystalline cellulose, add 70 mg of dextrin, 70 mg of lactose, and 7 mg of sodium carboxymethyl cellulose, and pass through a 60-mesh sieve. Mix evenly, use 85% ethanol as wetting agent to make soft material, pass through a 40-mesh sieve, oven-dry at 60°C for 5 hours, granulate with a 40-mesh sieve, and remove fine powder with a 60-mesh sieve to obtain 40-60-mesh granules. The critical relative humidity of the granules is below 78%, choose No. 1 capsule (0.50 ml) for filling, that is.

Embodiment 3

[0024] Embodiment 3 (tablet)

[0025] Adopt the technology of wet granulation, weigh the bamboo ginsenoside IVa powder prepared in Example 1, the mass ratio of lactose, microcrystalline cellulose, sodium carboxymethyl cellulose and magnesium stearate is: 10:25:83: 6:0.8. Pass the ginseng saponin IVa powder through a 100-mesh sieve, respectively pass through the lactose, microcrystalline cellulose, sodium carboxymethyl cellulose and magnesium stearate through a 60-mesh sieve, and put the obtained uniform powders into clean containers respectively. Soft powder made from 75% ethanol, granulated with a 18-24 mesh sieve, dried at 60°C for 2-4 hours, granulated with a 18-24 mesh sieve, mixed with micronized silica gel and magnesium stearate, pressed into tablets, that is Get a core.

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PUM

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Abstract

The invention discloses an application of panax japonicus saponin IVa in preparation of drug for treating nephritis or renal fibrosis drug. The panax japonicus saponin IVa is extractive of Aralia taibaiensis; study of an inventor finds that the panax japonicus saponin IVa has liver protection effect. The extracting method of the panax japonicus saponin IVa is simple, and the panax japonicus saponin IVa can inhibit expressions of MCP-1, TNF-alpha, 1L-6 inflammatory factors of NRK-49F cells induced by TGF-beta 1, reduce the renal interstitial fibrosis of UUO mice, and treat nephritis or renal fibrosis caused by various reasons; the effect is significant.

Description

technical field [0001] The present invention relates to the new use of bamboo ginseng saponin IVa for preventing and treating nephritis or renal fibrosis. Background technique [0002] Chronic renal failure (CRF) has become one of the major diseases affecting human health worldwide. Renal interstitial fibrosis is one of the TCM pathological features of CRF. How to use drugs to intervene in the development of renal interstitial fibrosis is the key to preventing and treating CRF. Renal fibrosis is an essential pathway of CRF, and a common pathway for the development of various kidney diseases to end-stage renal disease. At present, it is believed that the pathological changes of end-stage renal disease are irreversible, therefore, it is very important to control the occurrence and development of renal fibrosis. The pathogenesis of renal fibrosis is extremely complex, and it is a slow process of multi-links and multi-factor interactions. The main mechanisms include: inflamma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P13/12C07H15/256C07H1/08C07J63/00
CPCA61K31/704C07H1/08C07H15/256C07J63/008
Inventor 窦芳文爱东丁一顾向锋许航刘文星刘天龙
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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