Eye cream for dry eyes as well as preparation method and application of eye cream

A dry eye cream, dry eye technology, applied in the directions of pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc.

Pending Publication Date: 2021-07-06
邵毅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, d-borneol (borneol camphor extract) is mainly used in eye drops and eye protection patches on the market, and there are almost no eye cream products made with it.

Method used

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  • Eye cream for dry eyes as well as preparation method and application of eye cream
  • Eye cream for dry eyes as well as preparation method and application of eye cream
  • Eye cream for dry eyes as well as preparation method and application of eye cream

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-5

[0054] The formula components involved in embodiment 1-5 are as shown in table 1.

[0055] The formula of table 1 embodiment 1-5

[0056]

[0057] The preparation method is as follows:

[0058] 1) Preparation of borneol camphor extract (dextroborneol): extracting dextroborneol from borneol camphor by steam distillation. The specific process is described as follows: Weigh 100g of borneol camphor leaves, wash them with distilled water, grind them with scissors, put them into a three-necked flask, add 800mL of distilled water, control the temperature at 115°C and heat at a constant temperature, stop heating after 1h, and filter with ethyl acetate. The obtained solution was washed, dried by adding an appropriate amount of anhydrous sodium sulfate, and vacuum-dried to obtain the crude natural borneol. The crude product was eluted using petroleum ether-ethyl acetate (mass ratio: 200:1) silica gel column chromatography gradient to obtain borneol (dextroborneol).

[0059] 2) Pre...

Embodiment 6

[0066] Stability, safety and animal experiment curative effect evaluation of embodiment 6 d-borneol eye cream

[0067] Therapeutic effect of dexborneol eye cream on dry eye mice

[0068] Establishment of benzalkonium bromide dry eye model: female C57BL / 6 mice aged 10-12 weeks were instilled with 1 g / L benzalkonium bromide for 7 days, 3 times a day. The intervention group adopted the operation method of Example 1 to prepare D-borneol eye cream. Solvent group adopts the operation method of embodiment 1, increases E phase content to replace borneol camphor. Eye-dosing method: use a hair scraper to remove the hair around the eyes of the mouse, then use the above-mentioned eye cream, 3 times a day, and apply it to the eye area of ​​both eyes.

[0069] Apply D-Borneol eye cream to the eyes of benzalkonium bromide-induced dry eye model mice, compare dry eye group (DryEye), solvent group (Vehicle) and D-Borneol eye cream group (Borneol camphor) in the treatment Changes of various i...

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Abstract

The invention belongs to the technical field of research and development of skin care preparations, and particularly relates to eye cream for dry eyes as well as a preparation method and application of the eye cream. D-borneol (a borneol cinnamomum camphora extract) is used for preparing the eye cream, components are simple, dry eye treatment can be assisted, swelling and pain can be relieved, the smell can be used for refreshing and restoring consciousness, and a consumption range is wide; compared with eye drops and eye protection patches, the use is more convenient; and the eye cream is a skin care product so that the psychological stress of a patient can be reduced during use. The eye cream comprises a phase A, a phase B, a phase C, a phase D and a phase E; the phase A comprises 0.80%-1.25% of polydimethylsiloxane and 4.0%-15.0% of mineral ester; the phase B comprises 2.80%-5.50% of glycerol, 0.6%-1.7% of 1, 2-pentanediol, and 6.5%-14.0% of water; the phase C comprises 0.06%-2.02% of triethanolamine and 0.07%-1.05% of cetostearyl alcohol; the phase D is 0.05%-0.50% of d-borneol; and the phase E is the balance water; and the pH value is 5.0-7.0.

Description

technical field [0001] The invention belongs to the technical field of research and development of skin care preparations, and in particular relates to a dry eye cream, a preparation method and an application. Background technique [0002] The thinnest part of the human skin is the skin around the eyes, which is about a quarter of the thickness of the skin on the face. Due to the lack of sebaceous glands and sweat glands, the supply of oil content is small, which cannot meet the natural moisturizing needs of the skin around the eyes, making the skin around the eyes very easy to dry. At the same time, there are extremely rich capillaries and nerve endings distributed in the fibrous structure of the soft and elastic loose connective tissue under the skin around the eyes. The walls of these capillaries are very thin and have a certain degree of permeability, so they are easy to congest and accumulate water. Formation of hematoma or edema. [0003] Dry eye refers to the reduct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A61K8/891A61K8/31A61K8/41A61Q19/00A61K31/045A61K47/34A61K47/06A61K47/10A61K47/18A61P27/02
CPCA61K8/34A61K8/891A61K8/31A61K8/345A61K8/41A61K8/342A61Q19/005A61K31/045A61K47/34A61K47/06A61K47/10A61K47/18A61P27/02A61K2800/30
Inventor 邵毅唐丽颖邹雨婷袁蓉潘逸聪陈敏杰舒会叶葛倩敏
Owner 邵毅
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