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Novel diaryl nonane I free radical inhibitor in Saxifraga sinomontana as well as separation and preparation process and application of the novel diaryl nonane I free radical inhibitor

A technology of diarylnonane and preparation process is applied in the field of diarylnonane class I free radical inhibitor, and achieves the effects of low cost, easy operation, and easy batch preparation

Active Publication Date: 2021-07-09
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no literature report on the separation, preparation and application of free inhibitors in saxifrage

Method used

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  • Novel diaryl nonane I free radical inhibitor in Saxifraga sinomontana as well as separation and preparation process and application of the novel diaryl nonane I free radical inhibitor
  • Novel diaryl nonane I free radical inhibitor in Saxifraga sinomontana as well as separation and preparation process and application of the novel diaryl nonane I free radical inhibitor
  • Novel diaryl nonane I free radical inhibitor in Saxifraga sinomontana as well as separation and preparation process and application of the novel diaryl nonane I free radical inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The separation and preparation process of the new diarylnonane class I free radical inhibitor in saxifrage, specifically includes the following steps:

[0043] Step 1, extraction: take 170g of saxifrage whole herb and dry it in the shade, coarsely crush it and extract it with methanol at a solid-to-liquid ratio of 1g: 5mL, extract 4 times at room temperature, each time for 2h, filter and combine the filtrates, that is, filtrate A, the The filtrate A is dried under reduced pressure to obtain the saxifrage extract, according to the amount of polyamide: the amount of the saxifrage extract=3:1, mix the sample and dry under reduced pressure, and then the mixed sample of the saxifrage extract is obtained ; Among them, the conditions of the two decompression drying are: vacuum degree 50mbar, temperature 40°C, and the mixed sample of the obtained saxifrage extract is 70.8g;

[0044] Step 2, online free radical inhibitor component screening: Add methanol with a volume concentrat...

Embodiment 2

[0050] The separation and preparation process of the new diarylnonane class I free radical inhibitor in saxifrage, specifically includes the following steps:

[0051] Step 1, extraction: take 500g of saxifrage whole herb and dry it in the shade, coarsely crush it and extract it according to the ratio of solid to liquid: 1g: 100mL of methanol, extract twice at room temperature, each time for 4h, filter and combine the filtrates, that is, filtrate A, the The filtrate A is dried under reduced pressure to obtain the saxifrage extract, according to the amount of polyamide: the amount of the saxifrage extract=3:1, mix the sample and dry under reduced pressure, and then the mixed sample of the saxifrage extract is obtained ; Among them, the conditions of the two decompression drying are: the vacuum degree is 250mbar, the temperature is 60°C, and the mixed sample of the obtained saxifrage extract is 198.5g;

[0052] Step 2, online free radical inhibitor component screening: add methan...

Embodiment 3

[0058] The separation and preparation process of the new diarylnonane class I free radical inhibitor in saxifrage, specifically includes the following steps:

[0059] Step 1, extraction: take 1000g of saxifrage whole herb and dry it in the shade, coarsely crush it and extract it according to the ratio of solid to liquid: 1g: 50mL of methanol, extract 3 times at room temperature, each time for 3h, filter and combine the filtrates, that is, filtrate A, the The filtrate A is dried under reduced pressure to obtain the saxifrage extract, according to the amount of polyamide: the amount of the saxifrage extract = 3:1, mix the sample and dry under reduced pressure to obtain the mixed sample of the saxifrage extract ; Among them, the conditions of the two decompression drying are: the vacuum degree is 100mbar, the temperature is 50°C, and the mixed sample of the obtained saxifrage extract is 389.4g;

[0060]Step 2, online free radical inhibitor component screening: add methanol with a...

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Abstract

The invention discloses a novel diaryl nonane I free radical inhibitor in Saxifraga sinomontana as well as a separation and preparation process and application of the diaryl nonane I free radical inhibitor. The specific preparation process comprises the following five steps: extraction, on-line free radical inhibitor component screening, medium-pressure chromatography coarse separation in a microporous resin column, on-line free radical inhibitor screening and reversed-phase preparative column preparation. The novel diaryl nonane Saximonsin A free radical inhibitor in the Saxifraga sinomontana, prepared by the method, can be applied to preparation of free radical inhibition medicines or health foods, and is specifically used as an effective component to be prepared into various medicinal preparations or health foods according to any pharmaceutically or food science acceptable carrier. An extraction solvent, a microporous resin column, a reversed-phase chromatographic column separation solvent and materials for reversed-phase chromatographic separation in the preparation process can be recycled; the raw material source is wide, large-scale operation can be realized in the process steps such as methanol room-temperature cold leaching extraction, and high-pressure reversed-phase preparative chromatography separation can ensure that the purity of the product is greater than 95%.

Description

technical field [0001] The invention relates to the technical field of separation of new diarylnonane free radical inhibitors in saxifrage, in particular to a new diarylnonane I free radical inhibitor in saxifrage and its separation and preparation process and application. Background technique [0002] Saxifraga montana is a perennial herb of Saxifragaceae (Saxifragaceae) genus Saxifraga, Tibetan medicine name: "Hanrenjiaomu", mainly distributed in Shaanxi, Qinghai, and western Sichuan in China , northwestern Yunnan and eastern and southern Tibet. Main effects: clearing heat and detoxifying, calming the liver and suppressing yang. Cure mainly damp-heat in the liver and gallbladder, damp-heat in the spleen and stomach, carbuncle and sores are used for headaches caused by hyperactivity of liver-yang. Modern pharmacological studies have proved that phenols are the main active ingredients of saxifrage plants. According to literature reports, phenolic compounds have good free...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/248C07C45/80C07C45/79A61P39/06A23L33/105
CPCC07C49/248A61P39/06A23L33/105A23V2002/00A23V2200/30A23V2250/21Y02A50/30
Inventor 党军王启兰陶燕铎
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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