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Medicine for preventing or/and treating coronavirus infection and preparation method thereof

A coronavirus and drug technology, applied in the field of biomedicine, can solve problems such as species selection restrictions, and achieve the effect of inhibiting coronavirus

Active Publication Date: 2021-07-13
THE HONG KONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are currently few types of coronaviruses used for the prevention and / or treatment of coronaviruses, and the selection of drugs for epidemic prevention is greatly limited

Method used

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  • Medicine for preventing or/and treating coronavirus infection and preparation method thereof
  • Medicine for preventing or/and treating coronavirus infection and preparation method thereof
  • Medicine for preventing or/and treating coronavirus infection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0057] The embodiment of the present invention also relates to a preparation method of the medicament for preventing or / and treating coronavirus infection, the preparation method comprising the following steps: decocting the medicinal material with water, and collecting the medicinal liquid.

[0058] In one example, the mass of water is 10 to 15 times the mass of the medicinal material, the number of decoctions is 1 to 3 times, and the duration of each decoction is 0.8 hours to 1.2 hours. For example, add 12 times the amount of water to the medicinal material, and decoct it twice for 1 hour each time.

[0059] In one example, the preparation method further includes the step of preparing the medicinal solution into decoction, infusion, tablet or capsule.

[0060] The embodiment of the present invention relates to the use of trigepicin or / and fotanmu in the preparation of medicaments for preventing or / and treating coronavirus infection.

[0061] A medicament for preventing and / ...

Embodiment 1

[0067] Embodiment 1, the aqueous extract of single flavor Chinese medicinal material

[0068] Prepare winter mulberry leaf water extract, silver flower vine water extract, ghost needle grass water extract, houttuynia cordata water extract, soil achyranthes bidentata water extract, loquat leaf water extract, five-finger mandarin orange water extract, wild chrysanthemum flower water Extract, water extract of white paper fan, water extract of Jinsha vine, water extract of Duckfoot wood, water extract of Tianjihuang water extract, water extract of cloth dregs leaf, water extract of three-fork bitterness, water extract of money grass, light bamboo leaf Water extract, emblica water extract, Gangmei root water extract, yellow ox tea water extract, wood root water extract, mountain sesame water extract, gourd tea water extract, dandelion water extract and fire charcoal mother water extract .

[0069] The preparation method of water extract comprises the steps:

[0070] (1) Take medi...

Embodiment 2

[0073]Embodiment 2, Chinese medicine prescription A

[0074] (1) According to the proportions of medicinal materials listed in Table 1, weigh them, add 12 times the mass of water to soak for half an hour, heat and boil for 1 hour, and then filter out the medicinal liquid after separating the medicinal residues.

[0075] (2) Add the same amount of medicinal residues (that is, add 12 times the mass of medicinal materials) water, heat and boil for 1 hour, and then separate the medicinal residues to filter out the medicinal liquid.

[0076] (3) Merge liquid medicine.

[0077] (4) Extract 25mL of the drug solution into a 50mL centrifuge tube, place in a -80°C refrigerator for 24 hours, then transfer to a freeze dryer, and freeze-dry for 1 week until all the drug solution is dried to powder.

[0078] Table 1

[0079]

[0080]

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Abstract

The invention relates to a medicine for preventing or / and treating coronavirus infection and a preparation method thereof. In the traditional Chinese medicine research process, the inventor finds that common Lingnan medicinal materials including Chinese knotweed herb, emblic leafflower fruit, evodia lepta, roughhaired holly root, lysimachia christinae hance, lygodium japonicum, cratoxylum cochinchinense, desmodium triquetrum, loquat leaf and hypericum japonicum can reduce spike protein of the coronavirus and reduce combination of spike protein and angiotensin converting enzyme 2 so that the effect of inhibiting the coronavirus can be achieved. Based on the discovery, the medicinal materials and the traditional Chinese medicine composition containing the medicinal materials are used for preparing the medicine for preventing or / and treating the coronavirus infection, and a new solution is provided for controlling the coronavirus infection.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a traditional Chinese medicine composition, in particular to a medicine for preventing or / and treating coronavirus infection and a preparation method thereof. Background technique [0002] Coronaviruses are a large family of viruses known to cause more serious illnesses such as colds, Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). The novel coronavirus is a new strain of coronavirus that has never been found in humans before. The International Committee on Taxonomy of Viruses named this new pathogen Severe Acute Respiratory Syndrome Coronavirus 2 (severe acute respiratory syndrome coronavirus 2) or SARS-CoV-2, which is referred to as "new coronavirus" for short in the present invention. [0003] Common signs of people infected with the new coronavirus (SARS-CoV-2) include respiratory symptoms, fever, cough, shortness of breath, and dyspnea. In more...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/38A61K36/48A61K36/704A61K36/47A61K36/754A61K36/53A61K36/73A61K36/78A61P31/14
CPCA61K36/12A61K36/38A61K36/48A61K36/704A61K36/47A61K36/754A61K36/185A61K36/53A61K36/73A61K36/78A61P31/14A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 詹华强董婷霞梁嘉荣段然邓伟麟李芷晴林彤姿司徒嘉珈
Owner THE HONG KONG UNIV OF SCI & TECH
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