Application of beautiful millettia root in preparation of medicine for treating hepatic fibrosis

A technology of Niu Dali and purpose, applied in the application of Niu Dali in the field of pharmaceutical use, and the application of Niu Dali in the field of pharmacodynamics, can solve the problem that the mechanism of the effective part of liver fibrosis against liver fibrosis is not completely determined and so on.

Pending Publication Date: 2021-07-27
杨增艳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, so far, the effective part of Niu Dali on liver fibrosis and its anti-hepatic fibrosis mechanism have not been fully determined.

Method used

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  • Application of beautiful millettia root in preparation of medicine for treating hepatic fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation of embodiment 1 Niu Dali n-butanol fraction 1

[0029] Take the coarse powder of Niu Dali medicinal material, soak in 8 times the amount of 70% ethanol for 30 minutes, heat and reflux for extraction for 1.5 hours, filter while it is hot, collect the filtrate, continue to heat and reflux the filter residue for 2 times, combine the 3 filtrates, and recover the ethanol. After concentration, the ethanol extract of Niu Dali is obtained. Extract with petroleum ether, ethyl acetate, and n-butanol in sequence, collect the n-butanol extract, and evaporate the n-butanol to obtain the n-butanol fraction.

Embodiment 2

[0030] The preparation of embodiment 2 Niu Dali n-butanol fraction 2

[0031] Take the coarse powder of Niu Dali medicinal material, soak in 8 times the amount of 70% ethanol for 30 minutes, heat and reflux for extraction for 1.5 hours, filter while it is hot, collect the filtrate, continue to heat and reflux the filter residue for 2 times, combine the 3 filtrates, and recover the ethanol. After concentration, the ethanol extract of Niu Dali is obtained. Sequentially extract with water and n-butanol, collect the n-butanol extract, and evaporate the n-butanol to obtain the n-butanol fraction.

Embodiment 3

[0032] The preparation of the ethyl acetate part of embodiment 3 cattle vigorously

[0033] Coarse powder of Niu Dali medicinal material, soaked in 8 times the amount of 70% ethanol for 30 minutes, heated and refluxed for 1.5 hours, filtered while hot, collected the filtrate, continued heating and refluxed the filter residue for 2 times, combined the 3 filtrates, recovered the ethanol, and concentrated After that, the ethanol extract of Niu Dali was obtained. Extract with petroleum ether, ethyl acetate, and n-butanol in sequence, collect the ethyl acetate extract, and evaporate the ethyl acetate to obtain the ethyl acetate fraction.

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Abstract

The invention discloses an application of an effective part extracted from beautiful millettia root in preparation of a medicine for treating hepatic fibrosis. The application is characterized in that the effective part extracted from the beautiful millettia root is one or a combination of more of a petroleum ether part, an ethyl acetate part and an n-butyl alcohol part. The ratio of the n-butyl alcohol part for inducing apoptosis of hepatic stellate cells is the highest and is higher than that of other parts, so that the anti-hepatic fibrosis effect of the n-butyl alcohol part of the beautiful millettia root is the strongest.

Description

Technical field: [0001] The invention belongs to the technical field of medicine, further belongs to the technical field of ethnic medicine, and more specifically relates to the pharmacodynamic application of Niu Dali, that is, the application of Niu Dali in the field of pharmaceutical use. Background technique: [0002] Zhuang medicine is the crystallization of experience formed by the ancestors of the Zhuang nationality during the long-term struggle against diseases. It is an important part of the splendid culture of the Zhuang nationality and plays an important role in the survival and reproduction of the Zhuang nationality. Niu Dali is one of the characteristic medicines of Zhuang medicine in my country. Niu Dali is commonly used in folks to treat low back pain, rheumatic bone pain, tuberculosis, chronic hepatitis and chronic gastritis. [0003] The Niu Dali involved in the present invention is the dried root of the Papilionaceae plant Millettia speciosa Champ. Nature i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/486A61P1/16
CPCA61K36/486A61K2236/333A61K2236/39A61K2236/55A61P1/16
Inventor 杨增艳
Owner 杨增艳
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