Evening primrose extract-containing composition for inhibiting helicobacter pylori, and preparation method and application thereof

A Helicobacter pylori, extract technology, applied in the field of biomedicine, can solve the problem that there is no method for inhibiting Helicobacter pylori

Pending Publication Date: 2021-07-30
无锡简玺生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] With the continuous improvement of people's living standards, the frequency of eating out, dining out, especially multi-person gatherings is increasing, coupled with China's catering culture, the risk of cross-infection of Helicobacter pylori has become increasingly prominent in recent years; according to According to incomplete statistics, the risk of Helicobacter pylori infection in China is over 50%. Currently, there is no better way to treat it except multiple antibiotics; almost all of the current breath freshening mouthwashes and breath freshening sprays on the market are not specific for pylori. Inhibition methods for Helicobacter, especially there is no oral spray that can both inhibit and be natural and safe

Method used

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  • Evening primrose extract-containing composition for inhibiting helicobacter pylori, and preparation method and application thereof
  • Evening primrose extract-containing composition for inhibiting helicobacter pylori, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Preparation of evening primrose extract pre-solution: in parts by weight, 0.3 part of evening primrose (OENOTHERA BIENNIS) seed extract was dissolved in water at a mass ratio of 1:10 to obtain a primrose extract pre-solution;

[0019] First mix 0.2 part of essence, 0.05 part of menthol and 1 part of poloxamer 407 and add to water to dissolve, then add 0.4 part of pepper (ZANTHOXYLUM BUNGEANUM) fruit extract, 0.4 Pomelo (CITRUS GRANDIS) fruit extract, stir quickly to dissolve; then add the evening primrose extract pre-solution, wherein the evening primrose (OENOTHERA BIENNIS) seed extract is added in an amount of 0.3 parts, and then add 19.52 parts of side cheese milk Bacillus fermentation lysate (LACTOBACILLUS FERMENT LYSATE), 6.93 parts sorbitol, 2 parts xylitol, 1.6 parts glycerin, 0.5 parts 1,2-hexanediol, 0.2 parts 1,2-pentanediol, 0.08 parts Hydroxyacetophenone, 0.02 part of propolis extract, 0.007 part of aspartame, 0.004 part of stevioside; finally adding arginin...

Embodiment 2

[0040] Preparation of evening primrose extract pre-solution: Dissolve 0.1 part of evening primrose (OENOTHERA BIENNIS) seed extract in water according to the mass ratio of 1:10 to obtain pre-solution of primrose extract; first mix 0.2 part of essence, 0.05 part Mix menthol with 1 part of poloxamer 407 evenly, add water to dissolve, then add 0.25 parts of Zanthoxylum Bungeanum fruit extract and 0.25 part of pomelo (CITRUS GRANDIS) fruit extract when the temperature of the main pot is at 45 °C, Stir quickly to dissolve; then add the evening primrose extract pre-solution, wherein the evening primrose (OENOTHERA BIENNIS) seed extract addition is 0.1 part, then add 12 parts of Lactobacillus paracasei fermentation lysate, 5 parts of sorbose alcohol, 1 part xylitol, 0.5 part glycerin, 0.2 part 1,2-hexanediol, 0.05 part 1,2-pentanediol, 0.05 part p-hydroxyacetophenone, 0.01 part propolis extract, 0.003 part asparagus sweetin, 0.002 parts of stevioside; finally adding arginine to adjus...

Embodiment 3

[0042] Prepare evening primrose extract pre-solution: Dissolve 0.8 parts of evening primrose (OENOTHERA BIENNIS) seed extract in water according to the mass ratio of 1:10 to obtain pre-solution of primrose extract; first mix 0.2 parts of essence, 0.05 parts Mix menthol with 1 part of Poloxamer 407 evenly, add water to dissolve, and then add 0.8 part of Zanthoxylum Bungeanum fruit extract and 0.8 part of Citrus Grandis fruit extract when the temperature of the main pot is at 45 °C, Stir quickly to dissolve; then add the evening primrose extract pre-solution, wherein the addition of evening primrose (OENOTHERA BIENNIS) seed extract is 1 part, and then add 30 parts of Lactobacillus paracasei fermentation lysate, 12 parts of sorbose Alcohol, 5 parts of xylitol, 5 parts of glycerin, 1 part of 1,2-hexanediol, 1 part of 1,2-pentanediol, 0.5 parts of p-hydroxyacetophenone, 0.1 part of propolis extract, 0.05 parts of asparagus sweetin, 0.05 parts of stevioside; finally adding arginine ...

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Abstract

The invention discloses an evening primrose extract-containing composition for inhibiting helicobacter pylori, and a preparation method and application thereof. The composition is prepared from evening primrose seed extract, essence, poloxamer 407, a zanthoxylum bungeanum fruit extract, a pomelo fruit extract, lactobacillus paracasei fermentation lysate, sorbitol, xylitol, glycerol, 1, 2-hexanediol, 1, 2-pentanediol, p-hydroxyacetophenone, propolis extract, aspartame, stevioside, arginine, and the balance of water, and the pH value of the composition is 5.5-6.5. The prepared composition solution for inhibiting helicobacter pylori disclosed by the invention is stable in property, clear and transparent, excellent in sense, good in cool feeling, free of oral cavity irritation and long in sweet taste lasting time; andan oral spray for inhibiting helicobacter pylori adopts a natural plant component formula, so the oral spray can simultaneously improve oral malodor and oral micro-ecology, is safe and convenient, and achieves multiple purposes.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to a composition containing evening primrose extract for inhibiting Helicobacter pylori, a preparation method and application thereof. Background technique [0002] With the continuous improvement of people's living standards, the frequency of eating out, dining out, especially multi-person gatherings is increasing, coupled with China's catering culture, the risk of cross-infection of Helicobacter pylori has become increasingly prominent in recent years; according to According to incomplete statistics, the risk of Helicobacter pylori infection in China is over 50%. Currently, there is no better way to treat it except multiple antibiotics; almost all of the current breath freshening mouthwashes and breath freshening sprays on the market are not specific for pylori. The method of inhibiting Helicobacter, especially there is no mouth spray that can both inhibit and be na...

Claims

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Application Information

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IPC IPC(8): A61K36/758A61K36/185A61K9/12A61K47/18A61K47/10A61K47/28A61P1/02A61P31/02A61K35/747A61K35/644
CPCA61K36/185A61K36/758A61K36/752A61K35/747A61K35/644A61K9/006A61K47/183A61K47/10A61K47/28A61P1/02A61P31/02A61K9/12A61K2300/00
Inventor 简婷婷朱伟红
Owner 无锡简玺生物科技有限公司
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