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System for guiding individual precise medication of epilepsy disease

A technology of precise medication and antiepileptic drugs, applied in drug reference, drug or prescription, biochemical equipment and methods, etc., can solve problems such as poor curative effect, worry about side effects of antiepileptic drugs, and epilepsy patients not receiving reasonable treatment

Pending Publication Date: 2021-07-30
JINAN YING SHENG BIOTECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in developing countries, due to people's lack of correct understanding of epilepsy and lack of medical resources, most epilepsy patients have not received reasonable and effective formal treatment; about 4 million active epilepsy patients in my country have not received reasonable treatment
Among patients taking antiepileptic drugs, there are still some patients with unclear diagnosis or irregular treatment; patients are too worried about the side effects of antiepileptic drugs, and their medication compliance is poor, and they stop, reduce or change drugs at will
Some non-specialist doctors are inaccurate in the diagnosis and classification of epilepsy, the treatment is not standardized, the selection of drugs is inappropriate, and blindly using multi-drug therapy
The same drug and dose are often used for the same disease and the same group of people. Due to individual differences in drug response, some patients may have poor curative effect after medication, and even serious adverse reactions

Method used

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  • System for guiding individual precise medication of epilepsy disease
  • System for guiding individual precise medication of epilepsy disease
  • System for guiding individual precise medication of epilepsy disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] This embodiment provides a system for guiding individualized precise medication for epilepsy;

[0059] Such as figure 1 As shown, a system to guide individualized precision medicine for epilepsy, including:

[0060] A patient basic information acquisition module, which is configured to: acquire the patient's basic information;

[0061] The pharmacogenomic detection module is configured to: use the PGx kit to implement pharmacogenetic detection for epilepsy patients, and obtain polymorphism information of antiepileptic drug genes in patients;

[0062] a precision drug database configured to: store pharmacogenomics data, pharmacokinetics data, and pharmacodynamics data;

[0063] Preliminary drug regimen development module, which is configured to: based on the basic information of the patient, the polymorphism information of the patient's anti-epileptic drug gene and the information stored in the precision drug database; based on the principle of matching the input infor...

Embodiment 2

[0155] Example 2: The detection method of gene polymorphism based on MALDI-TOF mass spectrometry platform analysis for antiepileptic drug dosage regimen is applied to clinical cases

[0156] Patient A had adverse reactions in the central nervous system after taking the antiepileptic drug phenobarbital. Based on the MALDI-TOF nucleic acid mass spectrometry platform, the detection method of antiepileptic drug metabolism-related genotyping can detect patient A's antiepileptic drug metabolism-related The hotspot mutation site of the site, using the site variation information to guide patients to rational drug use, includes the following steps:

[0157] One, design the amplification primer shown in table 8, the extension primer shown in table 9 and the standard product nucleic acid sequence shown in table 10;

[0158] Table 8 Amplification primers of target gene sequence

[0159]

[0160]

[0161] Table 9 Extension primers for the target gene sequence

[0162]

[0163] T...

Embodiment 2

[0200] Embodiment two, such as figure 2 As shown, a system to guide individualized precision medicine for epilepsy, including:

[0201] A treatment information update module, which is configured to: obtain the preliminary drug regimen and the review result data after treatment;

[0202] The drug concentration monitoring module is configured to: implement blood drug concentration detection in epileptic patients, acquire and store drug concentration levels and metabolic capacity information data in the body of individual patients after using antiepileptic drugs;

[0203] The dosage regimen optimization module is configured to: call the information in the treatment information update module and the result information in the drug concentration monitoring module, and match the information with the information in the precise drug database according to the matching principle. The matching results are processed using the optimal drug administration decision tree model to obtain an o...

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Abstract

The invention provides a system for guiding individual precise medication of epilepsy, which adopts a drug genome detection technology to obtain genotypes of individual drug-related genomes; then, according to a drug genome database established by the inventor on the basis of big data, in combination with existing clinical medication guidelines or consensus of epilepsy diseases, the curative effect is predicted, side effects are early warned, and a preliminary precise medication scheme is formulated; finally, in the clinical medication process, drug concentration monitoring is conducted, the actual drug concentration in an individual body is obtained; and in combination with the clinical symptom improvement condition and the adverse reaction occurrence condition, the variety, dosage, frequency, administration route and the like of drugs are optimized and adjusted; therefore, on the basis of correct diagnosis of a specific patient and a specific disease, a correct drug is given and a correct dosage is used at a correct time, so that real individualized precise drug use is realized.

Description

technical field [0001] This application relates to the technical field of medical data processing, in particular to a system for guiding individualized and precise medication for epilepsy. Background technique [0002] The statements in this section merely mention the background art related to this application, and do not necessarily constitute the prior art. [0003] Epilepsy is a chronic brain disease caused by a variety of etiologies, characterized by recurrent, paroxysmal and transient central nervous system dysfunction caused by excessive discharge of brain neurons. Epilepsy occurs in people of any age, region and race, but the incidence is higher in children and adolescents. In recent years, with the aging of my country's population, the incidence of cerebrovascular diseases, dementia and neurodegenerative diseases has increased, and the incidence of epilepsy among the elderly has shown an upward trend. According to the World Health Organization (WHO) estimates, ther...

Claims

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Application Information

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IPC IPC(8): G16H70/40G16H20/10G16B15/30G16B20/20C12Q1/6883C12N15/11
CPCG16H70/40G16H20/10G16B15/30G16B20/20C12Q1/6883C12Q2600/106C12Q2600/156
Inventor 赵志刚冯振景叶松弭兆元
Owner JINAN YING SHENG BIOTECH
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