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A kind of multilayer composite embolic microsphere

A multi-layer composite and microsphere technology, which is applied in the field of medicine, can solve the problems of inability to release multiple drugs sequentially, long degradation cycle, fast drug sustained release speed, etc., to achieve drug synergy, reduce toxic side effects, and prolong sustained release the effect of time

Active Publication Date: 2022-05-27
谢辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the shortcomings of the prior art such as single drug loading, inability to sequentially release multiple drugs, fast drug release speed, and long degradation cycle, the present invention adopts microsphere composite sustained release technology, multi-layer microsphere composite technology, and supplemented with sodium alginate Preparation of a Multilayer Double Composite Microsphere by Modification Technology

Method used

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  • A kind of multilayer composite embolic microsphere
  • A kind of multilayer composite embolic microsphere
  • A kind of multilayer composite embolic microsphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Preparation of PLGA microspheres

[0033] 1) Take 1 g of PLGA (55 / 45) with a viscosity of 0.35 dl / g, dissolve it in 33 ml of tetrahydrofuran, and prepare a tetrahydrofuran solution of 3% PLGA in mass volume fraction;

[0034] 2) Weigh 0.05g of cisplatin, add cisplatin into 5ml of dimethylformamide and stir evenly to prepare a solution with a mass volume fraction of 1%;

[0035]3) Place the PLGA solution in the outer casing sampling device of the coaxial casing of the electrostatic droplet device, place the cisplatin solution in the inner tube sampling device of the coaxial casing of the electrostatic droplet device, and set the forming voltage to 30kv , the inner diameter of the inner nozzle of the coaxial casing is 0.06mm, the inner diameter of the outer nozzle is 0.2mm, the injection speed is adjusted to 0.2mL / h, the annular electric ring is placed 2cm below the nozzle, and ethanol-water (volume ratio 9:1) ) receiver is placed 10cm directly below the nozzle to co...

Embodiment 2

[0044] (1) Preparation of PLGA microspheres

[0045] 1) Take 1 g of PLGA (50 / 50) with a viscosity of 0.35 dl / g, dissolve it in 20 ml of dichloromethane, and prepare a dichloromethane solution of 5% PLGA by mass and volume;

[0046] 2) Weigh 0.1 g of cisplatin, add cisplatin into 10 ml of dimethylformamide and stir evenly to prepare a solution with a mass volume fraction of 1%;

[0047] 3) Place the PLGA solution in the outer casing sampling device of the coaxial casing of the electrostatic droplet device, place the cisplatin solution in the inner tube sampling device of the coaxial casing of the electrostatic droplet device, and set the forming voltage to 25kv , the inner diameter of the inner nozzle of the coaxial casing is 0.06mm, the inner diameter of the outer nozzle is 0.2mm, the injection speed is adjusted to 2mL / h, the annular electric ring is placed 2cm below the nozzle, and ethanol-water (volume ratio 9:1) The receiver is placed 10cm directly below the nozzle to coll...

Embodiment 3

[0056] (1) Preparation of PLGA microspheres

[0057] 1) Take 2 g of PLGA (55 / 45) with a viscosity of 0.1 dl / g, dissolve it in 40 ml of tetrahydrofuran, and prepare a tetrahydrofuran solution of 5% PLGA by mass volume fraction;

[0058] 2) Weigh 0.2g of cisplatin, add cisplatin into 10ml of dimethylformamide and stir evenly to prepare a solution with a mass volume fraction of 2%;

[0059] 3) Place the PLGA solution in the outer casing sampling device of the coaxial casing of the electrostatic droplet device, place the cisplatin solution in the inner tube sampling device of the coaxial casing of the electrostatic droplet device, and set the forming voltage to 10kv , the inner diameter of the inner nozzle of the coaxial casing is 0.06mm, the inner diameter of the outer nozzle is 0.2mm, the injection speed is adjusted to 2mL / h, the annular electric ring is placed 2cm below the nozzle, and ethanol-water (volume ratio 9:1) The receiver is placed 10cm directly below the nozzle to co...

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Abstract

The invention relates to a multilayer composite embolic microsphere, which is composed of multilayer microspheres, and the multilayer composite embolic microspheres are as follows from inside to outside: PLGA core-shell drug-loaded microspheres, PLGA core-shell drug-loaded microspheres The modified sodium alginate microspheres, the carboxymethyl chitosan microspheres wrapped in the modified sodium alginate layer, and the sodium alginate layer wrapped outside the carboxymethyl chitosan microspheres are composed. Through multi-layer drug loading and modified design of sodium alginate, the prepared microspheres can not only release drugs stably and uniformly for a long time, realize effective chemotherapy in the whole embolization cycle, but also can load different drugs to realize drug release in sequence, reducing toxicity side effects and achieve drug synergy.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a multi-layer composite embolization microsphere. Through the modified design of multi-layer drug loading and sodium alginate, the prepared microspheres can not only release the drug stably and uniformly for a long time, and realize effective chemotherapy in the whole embolization cycle, but also can load different drugs to realize the sequential release of drugs and reduce toxicity. side effects and achieve drug synergy. Background technique [0002] Interventional tumor therapy is one of the main methods for the treatment of malignant tumors, and it is also the main means of non-surgical treatment of tumors. Interventional therapy technology integrates various disciplines such as medical imaging and clinical treatment. It is simple, safe, minimally invasive and has fewer complications after treatment. It has become one of the most important technologies in tumor interventional ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K47/34A61K47/36A61K45/00A61P35/00
CPCA61K9/5073A61K9/5036A61K9/5031A61K45/00A61P35/00A61K9/5089
Inventor 谢辉王君箫王华明田圣涛
Owner 谢辉
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